Homo sapiens Gene: FGF7
Summary
InnateDB Gene IDBG-11473.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGF7
Gene Name fibroblast growth factor 7
Synonyms HBGF-7; KGF;
Species Homo sapiens
Ensembl Gene ENSG00000140285
Encoded Proteins
fibroblast growth factor 7
fibroblast growth factor 7
fibroblast growth factor 7
fibroblast growth factor 7
fibroblast growth factor 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
FGF7 enhances alveolar host defence through GM-CSF-stimulated macrophage activation. Intrapulmonary FGF7 injection enhanced the clearance of E. coli or P. aeruginosa via the augmented recruitment, phagocytic activity and oxidant responses of macrophages. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Fgf7 enhances alveolar host defence through GM-CSF-stimulated macrophage activation. Intrapulmonary Fgf7 injection enhanced the clearance of E. coli or P. aeruginosa via the augmented recruitment, phagocytic activity and oxidant responses of macrophages.
Entrez Gene
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:49423096-49488775
Strand Forward strand
Band q21.2
Transcripts
ENST00000267843 ENSP00000267843
ENST00000560270 ENSP00000454205
ENST00000560765 ENSP00000453048
ENST00000560979 ENSP00000453980
ENST00000560704
ENST00000614567 ENSP00000478148
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005104 fibroblast growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0042056 chemoattractant activity
Biological Process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008544 epidermis development
GO:0009611 response to wounding
GO:0010463 mesenchymal cell proliferation
GO:0010838 positive regulation of keratinocyte proliferation
GO:0031069 hair follicle morphogenesis
GO:0031532 actin cytoskeleton reorganization
GO:0034394 protein localization to cell surface
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0051549 positive regulation of keratinocyte migration
GO:0051781 positive regulation of cell division
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0061033 secretion by lung epithelial cell involved in lung growth
Cellular Component
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Signaling by FGFR mutants pathway
Activated point mutants of FGFR2 pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
FRS2-mediated cascade pathway
Phospholipase C-mediated cascade pathway
FGFR2b ligand binding and activation pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
PI3K Cascade pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
Insulin receptor signalling cascade pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-related events triggered by IGF1R pathway
SHC-mediated cascade pathway
IRS-related events pathway
Signaling by FGFR2 mutants pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by Insulin receptor pathway
Signaling by ERBB2 pathway
FGFR2 ligand binding and activation pathway
FGFR ligand binding and activation pathway
Negative regulation of FGFR signaling pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
MAPK signaling pathway pathway
Regulation of actin cytoskeleton pathway
Pathways in cancer pathway
Melanoma pathway
INOH
GPCR signaling pathway
FGF signaling pathway pathway
PID BIOCARTA
PID NCI
Glypican 3 network
Cross-References
SwissProt
TrEMBL H0YNE7
UniProt Splice Variant
Entrez Gene 2252
UniGene
RefSeq NM_002009
HUGO HGNC:3685
OMIM 148180
CCDS CCDS10131
HPRD
IMGT
EMBL AC022306 AC025919 AK313160 BC010956 CH471082 CR542002 M60828 S81661
GenPept AAA63210 AAB21431 AAH10956 BAG35978 CAG46799 EAW77375 EAW77376
RNA Seq Atlas 2252