InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FGF7

Summary

InnateDB Gene

IDBG-11473.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGF7

Gene Name

fibroblast growth factor 7

Synonyms

HBGF-7; KGF

Species

Homo sapiens

Ensembl Gene

ENSG00000140285

Encoded Proteins

IDBP-11475

fibroblast growth factor 7

IDBP-595538

fibroblast growth factor 7

IDBP-602624

fibroblast growth factor 7

IDBP-599401

fibroblast growth factor 7

IDBP-806989

fibroblast growth factor 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21343299

FGF7 enhances alveolar host defence through GM-CSF-stimulated macrophage activation. Intrapulmonary FGF7 injection enhanced the clearance of E. coli or P. aeruginosa via the augmented recruitment, phagocytic activity and oxidant responses of macrophages. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21343299

[Mus musculus] Fgf7 enhances alveolar host defence through GM-CSF-stimulated macrophage activation. Intrapulmonary Fgf7 injection enhanced the clearance of E. coli or P. aeruginosa via the augmented recruitment, phagocytic activity and oxidant responses of macrophages.

Entrez Gene

Summary

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:49423096-49488775

Strand

Forward strand

Band

q21.2

Transcripts

ENST00000267843	ENSP00000267843
ENST00000560270	ENSP00000454205
ENST00000560765	ENSP00000453048
ENST00000560979	ENSP00000453980
ENST00000560704
ENST00000614567	ENSP00000478148

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005104	fibroblast growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008201	heparin binding
GO:0042056	chemoattractant activity

Biological Process

GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0008544	epidermis development
GO:0009611	response to wounding
GO:0010463	mesenchymal cell proliferation
GO:0010838	positive regulation of keratinocyte proliferation
GO:0031069	hair follicle morphogenesis
GO:0031532	actin cytoskeleton reorganization
GO:0034394	protein localization to cell surface
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0050679	positive regulation of epithelial cell proliferation
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0051549	positive regulation of keratinocyte migration
GO:0051781	positive regulation of cell division
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0061033	secretion by lung epithelial cell involved in lung growth

Cellular Component

GO:0005576	extracellular region
GO:0005794	Golgi apparatus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027208

View Gene Order

ENSBTAG00000004013

Not yet available

Pathways

NETPATH

REACTOME

REACT_75829

PIP3 activates AKT signaling pathway

REACT_147814

DAP12 signaling pathway

REACT_147694

DAP12 interactions pathway

REACT_12464

PI3K/AKT activation pathway

REACT_12578

GAB1 signalosome pathway

REACT_9417

Signaling by EGFR pathway

REACT_115961

PI3K events in ERBB4 signaling pathway

REACT_115596

Signaling by ERBB4 pathway

REACT_976

PI3K Cascade pathway

REACT_498

Signaling by Insulin receptor pathway

REACT_150203

IRS-related events triggered by IGF1R pathway

REACT_150359

Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway

REACT_116008

PI3K events in ERBB2 signaling pathway

REACT_115755

Signaling by ERBB2 pathway

REACT_111184

Negative regulation of FGFR signaling pathway

REACT_21310

Phospholipase C-mediated cascade pathway

REACT_21374

SHC-mediated cascade pathway

REACT_21270

PI-3K cascade pathway

REACT_21247

FRS2-mediated cascade pathway

REACT_9416

FGFR2b ligand binding and activation pathway

REACT_9470

Signaling by FGFR pathway

REACT_111040

Signaling by SCF-KIT pathway

REACT_17025

Downstream signal transduction pathway

REACT_16888

Signaling by PDGF pathway

REACT_120863

Activated point mutants of FGFR2 pathway

REACT_121398

Signaling by FGFR mutants pathway

REACT_147727

Constitutive PI3K/AKT Signaling in Cancer pathway

REACT_120736

Signaling by FGFR in disease pathway

REACT_11061

Signalling by NGF pathway

REACT_115871

Signaling by EGFR in Cancer pathway

REACT_21272

Downstream signaling of activated FGFR pathway

REACT_163769

Role of LAT2/NTAL/LAB on calcium mobilization pathway

REACT_6802

Innate Immune System pathway

REACT_163936

Fc epsilon receptor (FCERI) signaling pathway

REACT_111102

Signal Transduction pathway

REACT_332

IRS-mediated signalling pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_1195

Insulin receptor signalling cascade pathway

REACT_12056

NGF signalling via TRKA from the plasma membrane pathway

REACT_762

IRS-related events pathway

REACT_121155

Signaling by FGFR2 mutants pathway

REACT_150210

IGF1R signaling cascade pathway

REACT_147723

PI3K/AKT Signaling in Cancer pathway

REACT_9390

FGFR2 ligand binding and activation pathway

REACT_9396

FGFR ligand binding and activation pathway

REACT_118773

Signaling by the B Cell Receptor (BCR) pathway

REACT_118638

Downstream signaling events of B Cell Receptor (BCR) pathway

REACT_116125

Disease pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04010

MAPK signaling pathway pathway

hsa05218

Melanoma pathway

hsa05200

Pathways in cancer pathway

INOH

INOH website

FGF signaling pathway pathway

INOH website

GPCR signaling pathway

PID NCI

glypican_3pathway

Glypican 3 network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_002009

HUGO

OMIM

CCDS

CCDS10131

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas