Homo sapiens Gene: RAD52
Summary
InnateDB Gene IDBG-11610.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD52
Gene Name RAD52 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000002016
Encoded Proteins
RAD52 homolog (S. cerevisiae)
RAD52 homolog (S. cerevisiae)
RAD52 homolog (S. cerevisiae)
RAD52 homolog (S. cerevisiae)
RAD52 homolog (S. cerevisiae)
RAD52 homolog (S. cerevisiae)
RAD52 homolog (S. cerevisiae)
RAD52 homolog (S. cerevisiae)
RAD52 homolog (S. cerevisiae)
RAD52 homolog (S. cerevisiae)
RAD52 homolog (S. cerevisiae)
RAD52 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. [provided by RefSeq, Jul 2008]
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:912077-990053
Strand Reverse strand
Band p13.33
Transcripts
ENST00000228345
ENST00000358495 ENSP00000351284
ENST00000397230 ENSP00000380407
ENST00000430095 ENSP00000387901
ENST00000468231 ENSP00000434703
ENST00000481052
ENST00000488642
ENST00000461568 ENSP00000436008
ENST00000463750
ENST00000535376
ENST00000542297
ENST00000543912 ENSP00000439583
ENST00000536177 ENSP00000440486
ENST00000542584
ENST00000545967
ENST00000542785 ENSP00000441073
ENST00000544742 ENSP00000443254
ENST00000541619 ENSP00000438965
ENST00000545629
ENST00000539259
ENST00000543290
ENST00000539046 ENSP00000445245
ENST00000545564 ENSP00000440268
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
Experimentally validated
Total 45 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000730 DNA recombinase assembly
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Homologous Recombination Repair pathway
Double-Strand Break Repair pathway
Homologous DNA pairing and strand exchange pathway
Homologous recombination repair of replication-independent double-strand breaks pathway
Presynaptic phase of homologous DNA pairing and strand exchange pathway
DNA Repair pathway
Assembly of the RAD51-ssDNA nucleoprotein complex pathway
KEGG
Homologous recombination pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P43351
TrEMBL D3DUP4 F5GX95 F5H3Q1 Q3MI84 Q5DR82 Q9UHE1
UniProt Splice Variant
Entrez Gene 5893
UniGene Hs.410355 Hs.560083
RefSeq NM_001297419 NM_001297420 NM_001297422 NM_134424 XM_005253720 XM_005253721 XM_005253725
HUGO HGNC:9824
OMIM 600392
CCDS CCDS8507
HPRD 11855
IMGT
EMBL AC004803 AF125948 AF125949 AF125950 AF187983 AK290047 AK292160 AK312026 AY527412 AY540753 BC104015 BC104017 CH471116 L33262 U12134 U27516
GenPept AAA85793 AAA87554 AAB05203 AAD24575 AAD24576 AAD24577 AAF05531 AAI04016 AAI04018 AAS00097 AAT44403 BAF82736 BAF84849 BAG34963 EAW88942 EAW88943 EAW88944 EAW88945 EAW88946 EAW88947 EAW88949 EAW88950
RNA Seq Atlas 5893