InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPARA

Summary

InnateDB Gene

IDBG-11786.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPARA

Gene Name

peroxisome proliferator-activated receptor alpha

Synonyms

hPPAR; NR1C1; PPAR; PPARalpha

Species

Homo sapiens

Ensembl Gene

ENSG00000186951

Encoded Proteins

IDBP-11788

peroxisome proliferator-activated receptor alpha

IDBP-295630

peroxisome proliferator-activated receptor alpha

IDBP-295621

peroxisome proliferator-activated receptor alpha

IDBP-380063

peroxisome proliferator-activated receptor alpha

IDBP-380065

peroxisome proliferator-activated receptor alpha

IDBP-380075

peroxisome proliferator-activated receptor alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:46150521-46243756

Strand

Forward strand

Band

q13.31

Transcripts

ENST00000262735	ENSP00000262735
ENST00000407236	ENSP00000385523
ENST00000402126	ENSP00000385246
ENST00000440343	ENSP00000397291
ENST00000415785	ENSP00000411677
ENST00000420804	ENSP00000414752
ENST00000460086
ENST00000496865
ENST00000484619
ENST00000481567
ENST00000493286
ENST00000624793

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	59 [view]
Protein-Protein	53 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004872	receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0008289	lipid binding
GO:0019902	phosphatase binding
GO:0019904	protein domain specific binding
GO:0031624	ubiquitin conjugating enzyme binding
GO:0032403	protein complex binding
GO:0043565	sequence-specific DNA binding
GO:0051525	NFAT protein binding
GO:0097371	MDM2/MDM4 family protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001666	response to hypoxia
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0007507	heart development
GO:0008544	epidermis development
GO:0010467	gene expression
GO:0010468	regulation of gene expression
GO:0010745	negative regulation of macrophage derived foam cell differentiation
GO:0010871	negative regulation of receptor biosynthetic process
GO:0010887	negative regulation of cholesterol storage
GO:0010891	negative regulation of sequestering of triglyceride
GO:0015908	fatty acid transport
GO:0019217	regulation of fatty acid metabolic process
GO:0030522	intracellular receptor signaling pathway
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0032091	negative regulation of protein binding
GO:0032099	negative regulation of appetite
GO:0032868	response to insulin
GO:0032922	circadian regulation of gene expression
GO:0035095	behavioral response to nicotine
GO:0042060	wound healing
GO:0042157	lipoprotein metabolic process
GO:0042752	regulation of circadian rhythm
GO:0043401	steroid hormone mediated signaling pathway
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045722	positive regulation of gluconeogenesis
GO:0045776	negative regulation of blood pressure
GO:0045820	negative regulation of glycolytic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046321	positive regulation of fatty acid oxidation
GO:0070166	enamel mineralization
GO:0072363	regulation of glycolysis by positive regulation of transcription from RNA polymerase II promoter
GO:0072366	regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369	regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:1901215	negative regulation of neuron death
GO:2000678	negative regulation of transcription regulatory region DNA binding