Homo sapiens Gene: TRPM7
Summary
InnateDB Gene IDBG-11807.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPM7
Gene Name transient receptor potential cation channel, subfamily M, member 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000092439
Encoded Proteins
transient receptor potential cation channel, subfamily M, member 7
transient receptor potential cation channel, subfamily M, member 7
transient receptor potential cation channel, subfamily M, member 7
transient receptor potential cation channel, subfamily M, member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:50552473-50686815
Strand Reverse strand
Band q21.2
Transcripts
ENST00000313478 ENSP00000320239
ENST00000561267 ENSP00000454066
ENST00000560955 ENSP00000453277
ENST00000561443
ENST00000560516
ENST00000558444
ENST00000560849
ENST00000560284
ENST00000560638 ENSP00000452873
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004674 protein serine/threonine kinase activity
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017022 myosin binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0016340 calcium-dependent cell-matrix adhesion
GO:0031032 actomyosin structure organization
GO:0034220 ion transmembrane transport
GO:0046777 protein autophosphorylation
GO:0055085 transmembrane transport
GO:0070266 necroptotic process
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0001726 ruffle
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Stimuli-sensing channels pathway
Ion channel transport pathway
TRP channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q96QT4
TrEMBL A0A024R5V1 H0YLN8
UniProt Splice Variant
Entrez Gene 54822
UniGene Hs.512894 Hs.734904
RefSeq NM_001301212 NM_017672 XM_005254488 XM_006720582
HUGO HGNC:17994
OMIM 605692
CCDS CCDS42035 CCDS73725
HPRD
IMGT
EMBL AC084756 AF346629 AK000124 AK075193 AK172800 AY032950 BC051024 CH471082
GenPept AAH51024 AAK19738 AAK44211 BAA90958 BAC11462 BAD18773 EAW77405 EAW77407 EAW77408
RNA Seq Atlas 54822