Homo sapiens Gene: SEH1L
Summary
InnateDB Gene IDBG-1204.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEH1L
Gene Name SEH1-like (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000085415
Encoded Proteins
SEH1-like (S. cerevisiae)
SEH1-like (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is part of a nuclear pore complex, Nup107-160. This protein contains WD repeats and shares 34% amino acid identity with yeast Seh1 and 30% identity with yeast Sec13. All constituents of the Nup107-160 complex, including this protein, specifically localize to kinetochores in mitosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:12947133-12987536
Strand Forward strand
Band p11.21
Transcripts
ENST00000262124 ENSP00000262124
ENST00000399892 ENSP00000382779
ENST00000585730 ENSP00000466959
ENST00000592170 ENSP00000467605
ENST00000592582
ENST00000587761 ENSP00000466234
ENST00000589446 ENSP00000467276
ENST00000590843
ENST00000588251
ENST00000590032
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0002534 cytokine production involved in inflammatory response
GO:0005975 carbohydrate metabolic process
GO:0006999 nuclear pore organization
GO:0007077 mitotic nuclear envelope disassembly
GO:0007080 mitotic metaphase plate congression
GO:0008645 hexose transport
GO:0010827 regulation of glucose transport
GO:0015031 protein transport
GO:0015758 glucose transport
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0044281 small molecule metabolic process
GO:0050830 defense response to Gram-positive bacterium
GO:0051028 mRNA transport
GO:0051315 attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
GO:0055085 transmembrane transport
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005635 nuclear envelope
GO:0005829 cytosol
GO:0031080 nuclear pore outer ring
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
RNA transport pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.301048 Hs.594046 Hs.708212 Hs.731967
RefSeq NM_001013437 NM_031216 XM_006722359
HUGO
OMIM
CCDS CCDS32791 CCDS45832
HPRD 15319
IMGT
EMBL
GenPept
RNA Seq Atlas