Homo sapiens Gene: FOXM1
Summary
InnateDB Gene IDBG-12457.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXM1
Gene Name forkhead box M1
Synonyms FKHL16; FOXM1B; HFH-11; HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29; TGT3; TRIDENT;
Species Homo sapiens
Ensembl Gene ENSG00000111206
Encoded Proteins
forkhead box M1
forkhead box M1
forkhead box M1
forkhead box M1
forkhead box M1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:2857681-2877040
Strand Reverse strand
Band p13.33
Transcripts
ENST00000342628 ENSP00000342307
ENST00000359843 ENSP00000352901
ENST00000361953 ENSP00000354492
ENST00000366362
ENST00000536066
ENST00000535350 ENSP00000442309
ENST00000538564 ENSP00000444541
ENST00000537018
ENST00000545049
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 39 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0001558 regulation of cell growth
GO:0001570 vasculogenesis
GO:0001889 liver development
GO:0006281 DNA repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007049 cell cycle
GO:0008284 positive regulation of cell proliferation
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0042127 regulation of cell proliferation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046578 regulation of Ras protein signal transduction
GO:0051726 regulation of cell cycle
GO:0071156 regulation of cell cycle arrest
GO:0090344 negative regulation of cell aging
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000781 positive regulation of double-strand break repair
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Cyclin A/B1 associated events during G2/M transition pathway
Cell Cycle pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
Polo-like kinase mediated events pathway
KEGG
INOH
PID BIOCARTA
PID NCI
FOXM1 transcription factor network
Cross-References
SwissProt Q08050
TrEMBL A8K591 H0YGS4 Q53Y49
UniProt Splice Variant
Entrez Gene 2305
UniGene Hs.239
RefSeq NM_001243088 NM_001243089 NM_021953 NM_202002 NM_202003 XM_005253676
HUGO HGNC:3818
OMIM 602341
CCDS CCDS8515 CCDS8516 CCDS8517
HPRD
IMGT
EMBL AC005841 AC005911 AK291206 AY542306 BC006192 BC006529 BC012863 BT006986 CH471116 DQ022289 L16783 U74612 U74613 U83113
GenPept AAC37541 AAC51128 AAC51129 AAC63595 AAH06192 AAH06529 AAH12863 AAP35632 AAT08175 AAY26401 BAF83895 EAW88880 EAW88883
RNA Seq Atlas 2305