Version 5.4
Homo sapiens Gene: DLST
Summary
InnateDB Gene IDBG-12474.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DLST
Gene Name dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Synonyms DLTS
Species Homo sapiens
Ensembl Gene ENSG00000119689
Encoded Proteins
IDBP-12476
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
IDBP-12480
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
IDBP-603495
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
IDBP-593013
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
IDBP-597409
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
IDBP-590859
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
IDBP-594272
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
IDBP-599936
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:74881891-74903745
Strand Forward strand
Band q24.3
Transcripts
ENST00000334220 ENSP00000335304
ENST00000238671 ENSP00000238671
ENST00000556460 ENSP00000451210
ENST00000555492 ENSP00000452417
ENST00000557012
ENST00000554612 ENSP00000451670
ENST00000556582
ENST00000555071
ENST00000556190
ENST00000555459
ENST00000555190
ENST00000555089 ENSP00000452422
ENST00000554806 ENSP00000451957
ENST00000555988 ENSP00000451425
ENST00000550473
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006099 tricarboxylic acid cycle
GO:0006554 lysine catabolic process
GO:0008152 metabolic process
GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0034641 cellular nitrogen compound metabolic process
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0016020 membrane
GO:0045252 oxoglutarate dehydrogenase complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004789
View Gene Order
ENSBTAG00000006463
Not yet available
Pathways
NETPATH
REACTOME
REACT_1298
Lysine catabolism pathway
REACT_1785
Citric acid cycle (TCA cycle) pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa00020
Citrate cycle (TCA cycle) pathway
hsa00310
Lysine degradation pathway
INOH
INOH website
Citrate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL B7ZAZ8
UniProt Splice Variant
Entrez Gene 1743
UniGene Hs.525459 Hs.619283
RefSeq NM_001933
HUGO HGNC:2911
OMIM 126063
CCDS CCDS9833
HPRD 00520
IMGT
EMBL AC006530 AK316463
GenPept BAH14834
RNA Seq Atlas 1743

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca