Homo sapiens Gene: CTNND2
Summary
InnateDB Gene IDBG-12568.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTNND2
Gene Name catenin (cadherin-associated protein), delta 2
Synonyms GT24; NPRAP;
Species Homo sapiens
Ensembl Gene ENSG00000169862
Encoded Proteins
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome.[provided by RefSeq, Aug 2010]
This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:10971840-11904043
Strand Reverse strand
Band p15.2
Transcripts
ENST00000304623 ENSP00000307134
ENST00000458100 ENSP00000391155
ENST00000495388
ENST00000513588 ENSP00000421093
ENST00000511377 ENSP00000426510
ENST00000504499 ENSP00000421000
ENST00000503622 ENSP00000426887
ENST00000506324
ENST00000504354
ENST00000502551 ENSP00000422389
ENST00000506735
ENST00000507430
ENST00000511278
ENST00000514132
ENST00000513598 ENSP00000426625
ENST00000508761 ENSP00000424296
ENST00000509868
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0001763 morphogenesis of a branching structure
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007612 learning
GO:0016337 single organismal cell-cell adhesion
GO:0048167 regulation of synaptic plasticity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005912 adherens junction
GO:0014069 postsynaptic density
GO:0043005 neuron projection
GO:0043204 perikaryon
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL D6R9A8 D6RF55 E7EPC8
UniProt Splice Variant
Entrez Gene 1501
UniGene Hs.314543 Hs.595576 Hs.713147
RefSeq NM_001288715 NM_001288716 NM_001288717 NM_001332
HUGO HGNC:2516
OMIM 604275
CCDS CCDS75228 CCDS3881 CCDS75227
HPRD 09181
IMGT
EMBL AC003954 AC004633 AC004648 AC005367 AC005610 AC010433 AC010626 AC113390 AC127460
GenPept
RNA Seq Atlas 1501