Version 5.4
Mus musculus Gene: Dnmt3a
Summary
InnateDB Gene IDBG-127800.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dnmt3a
Gene Name DNA methyltransferase 3A
Synonyms MmuIIIA
Species Mus musculus
Ensembl Gene ENSMUSG00000020661
Encoded Proteins
IDBP-127804
DNA methyltransferase 3A
IDBP-258657
DNA methyltransferase 3A
IDBP-622376
DNA methyltransferase 3A
IDBP-622421
DNA methyltransferase 3A
IDBP-622427
DNA methyltransferase 3A
IDBP-622434
DNA methyltransferase 3A
IDBP-622437
DNA methyltransferase 3A
IDBP-622438
DNA methyltransferase 3A
IDBP-622439
DNA methyltransferase 3A
IDBP-622442
DNA methyltransferase 3A
IDBP-622443
DNA methyltransferase 3A
IDBP-622445
DNA methyltransferase 3A
IDBP-622446
DNA methyltransferase 3A
IDBP-622447
DNA methyltransferase 3A
IDBP-622448
DNA methyltransferase 3A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:3806007-3914443
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000020991 ENSMUSP00000020991
ENSMUST00000085826
ENSMUST00000111186 ENSMUSP00000106817
ENSMUST00000173700
ENSMUST00000172719 ENSMUSP00000133501
ENSMUST00000172509 ENSMUSP00000133869
ENSMUST00000174817 ENSMUSP00000134009
ENSMUST00000174483 ENSMUSP00000133938
ENSMUST00000172816 ENSMUSP00000134632
ENSMUST00000173197 ENSMUSP00000133567
ENSMUST00000174102 ENSMUSP00000134480
ENSMUST00000172689 ENSMUSP00000133543
ENSMUST00000172879 ENSMUSP00000134689
ENSMUST00000174774 ENSMUSP00000134529
ENSMUST00000172749 ENSMUSP00000134567
ENSMUST00000174272
ENSMUST00000174733 ENSMUSP00000134492
ENSMUST00000172913 ENSMUSP00000134496
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 27 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0045322 unmethylated CpG binding
GO:0046872 metal ion binding
GO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006306 DNA methylation
GO:0006346 methylation-dependent chromatin silencing
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006351 transcription, DNA-templated
GO:0007283 spermatogenesis
GO:0010216 maintenance of DNA methylation
GO:0010424 DNA methylation on cytosine within a CG sequence
GO:0043045 DNA methylation involved in embryo development
GO:0043046 DNA methylation involved in gamete generation
GO:0044027 hypermethylation of CpG island
GO:0046498 S-adenosylhomocysteine metabolic process
GO:0046499 S-adenosylmethioninamine metabolic process
GO:0071230 cellular response to amino acid stimulus
GO:0090116 C-5 methylation of cytosine
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005720 nuclear heterochromatin
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000119772
View Gene Order
ENSBTAG00000021143
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_222475
PRC2 methylates histones and DNA pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_233572
Gene Expression pathway
REACT_268475
DNA methylation pathway
REACT_244207
RMTs methylate histone arginines pathway
KEGG
mmu00270
Cysteine and methionine metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_200808
PRC2 methylates histones and DNA pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_267652
DNA methylation pathway
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_71
Gene Expression pathway
KEGG
hsa00270
Cysteine and methionine metabolism pathway
INOH
PID NCI
myc_represspathway
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.408117 Mm.421724 Mm.454591 Mm.454592 Mm.470389 Mm.5001
RefSeq NM_001271753 NM_007872 NM_153743 XM_006514953 XM_006514954 XM_006514955 XM_006514956 XM_006514957
OMIM
CCDS CCDS25784 CCDS36397
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca