Version 5.4
Mus musculus Gene: Wac
Summary
InnateDB Gene IDBG-128123.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wac
Gene Name WW domain containing adaptor with coiled-coil
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000024283
Encoded Proteins
IDBP-128125
WW domain containing adaptor with coiled-coil
IDBP-128127
WW domain containing adaptor with coiled-coil
IDBP-621232
WW domain containing adaptor with coiled-coil
IDBP-621234
WW domain containing adaptor with coiled-coil
IDBP-621235
WW domain containing adaptor with coiled-coil
IDBP-621236
WW domain containing adaptor with coiled-coil
IDBP-621237
WW domain containing adaptor with coiled-coil
IDBP-621239
WW domain containing adaptor with coiled-coil
IDBP-621240
WW domain containing adaptor with coiled-coil
IDBP-621241
WW domain containing adaptor with coiled-coil
IDBP-621242
WW domain containing adaptor with coiled-coil
IDBP-621243
WW domain containing adaptor with coiled-coil
IDBP-621244
WW domain containing adaptor with coiled-coil
IDBP-621245
WW domain containing adaptor with coiled-coil
IDBP-621246
WW domain containing adaptor with coiled-coil
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095787:
The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:7868832-7973547
Strand Forward strand
Band A1
Transcripts
ENSMUST00000092112 ENSMUSP00000089746
ENSMUST00000074919 ENSMUSP00000074454
ENSMUST00000171042 ENSMUSP00000133185
ENSMUST00000166378 ENSMUSP00000128060
ENSMUST00000171486 ENSMUSP00000127848
ENSMUST00000170932 ENSMUSP00000127434
ENSMUST00000167020 ENSMUSP00000132117
ENSMUST00000165572
ENSMUST00000172018 ENSMUSP00000128321
ENSMUST00000168446 ENSMUSP00000131032
ENSMUST00000166062 ENSMUSP00000132532
ENSMUST00000169010 ENSMUSP00000131750
ENSMUST00000165854 ENSMUSP00000126815
ENSMUST00000170854 ENSMUSP00000131141
ENSMUST00000167057
ENSMUST00000167542 ENSMUSP00000125989
ENSMUST00000169478 ENSMUSP00000130467
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000993 RNA polymerase II core binding
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0010390 histone monoubiquitination
GO:0016239 positive regulation of macroautophagy
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0044783 G1 DNA damage checkpoint
GO:0045893 positive regulation of transcription, DNA-templated
GO:0071894 histone H2B conserved C-terminal lysine ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000095787
View Gene Order
ENSBTAG00000018263
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.272685 Mm.410713 Mm.438316 Mm.490814
RefSeq NM_001146298 NM_001282093 NM_153085 XM_006525803 XM_006525804 XM_006525805
OMIM
CCDS CCDS29046 CCDS50218 CCDS70869
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca