Version 5.4
Mus musculus Gene: Lifr
Summary
InnateDB Gene IDBG-128297.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lifr
Gene Name leukemia inhibitory factor receptor
Synonyms A230075M04Rik; AW061234; LIF
Species Mus musculus
Ensembl Gene ENSMUSG00000054263
Encoded Proteins
IDBP-128299
leukemia inhibitory factor receptor
IDBP-621545
leukemia inhibitory factor receptor
IDBP-621547
leukemia inhibitory factor receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113594:
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:7129559-7197489
Strand Forward strand
Band A1
Transcripts
ENSMUST00000067190 ENSMUSP00000064551
ENSMUST00000171588 ENSMUSP00000126137
ENSMUST00000164529 ENSMUSP00000131434
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004897 ciliary neurotrophic factor receptor activity
GO:0004923 leukemia inhibitory factor receptor activity
GO:0004924 oncostatin-M receptor activity
GO:0005127 ciliary neurotrophic factor receptor binding
GO:0005515 protein binding
GO:0019838 growth factor binding
Biological Process
GO:0008284 positive regulation of cell proliferation
GO:0019221 cytokine-mediated signaling pathway
GO:0034097 response to cytokine
GO:0038165 oncostatin-M-mediated signaling pathway
GO:0048861 leukemia inhibitory factor signaling pathway
GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113594
View Gene Order
ENSBTAG00000010423
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
LIF signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_114
Oncostatin_M pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
LIF signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.149720 Mm.397687 Mm.414408 Mm.415733 Mm.472431 Mm.472667
RefSeq NM_001113386 NM_013584 XM_006519967 XM_006519968 XM_006519969 XM_006519970 XM_006519971
OMIM
CCDS CCDS27369 CCDS49577
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca