InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gdi2

Summary

InnateDB Gene

IDBG-128348.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gdi2

Gene Name

guanosine diphosphate (GDP) dissociation inhibitor 2

Synonyms

GDI-B; Gdi3; GDIB

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021218

Encoded Proteins

IDBP-128350

guanosine diphosphate (GDP) dissociation inhibitor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000057608:
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:3538075-3566261

Strand

Forward strand

Band

Transcripts

ENSMUST00000059515

ENSMUSP00000062996

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005093	Rab GDP-dissociation inhibitor activity
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding
GO:0031267	small GTPase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0032851	positive regulation of Rab GTPase activity
GO:0050790	regulation of catalytic activity