Version 5.4
Mus musculus Gene: Ucn3
Summary
InnateDB Gene IDBG-128525.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ucn3
Gene Name urocortin 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000044988
Encoded Proteins
IDBP-128527
urocortin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178473:
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:3940688-3945349
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000058610 ENSMUSP00000049678
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005184 neuropeptide hormone activity
GO:0005515 protein binding
GO:0051431 corticotropin-releasing hormone receptor 2 binding
Biological Process
GO:0006950 response to stress
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007586 digestion
GO:0009749 response to glucose
GO:0031669 cellular response to nutrient levels
GO:0032024 positive regulation of insulin secretion
GO:0035902 response to immobilization stress
GO:0042594 response to starvation
GO:0045838 positive regulation of membrane potential
GO:0051412 response to corticosterone
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005615 extracellular space
GO:0030424 axon
GO:0043005 neuron projection
GO:0043196 varicosity
GO:0043679 axon terminus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000178473
View Gene Order
ENSBTAG00000035696
Not yet available
Cross-References
SwissProt Q924A4
TrEMBL Q0VDY5 Q3UFJ9
UniProt Splice Variant
Entrez Gene 83428
UniGene Mm.313662
RefSeq NM_031250
OMIM
CCDS CCDS26217
HPRD
IMGT
MGI ID MGI:1932970
MGI Symbol Ucn3
EMBL AF361944 AK148451 BC119433 BC119434 CH466588
GenPept AAI19434 AAI19435 AAK67318 BAE28561 EDL32235
RNA Seq Atlas 83428

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca