InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rbbp8

Summary

InnateDB Gene

IDBG-128600.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbbp8

Gene Name

retinoblastoma binding protein 8

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041238

Encoded Proteins

IDBP-128602

retinoblastoma binding protein 8

IDBP-248713

retinoblastoma binding protein 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101773:
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:11633276-11743207

Strand

Forward strand

Band

Transcripts

ENSMUST00000047322	ENSMUSP00000046255
ENSMUST00000115861	ENSMUSP00000111527

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000014	single-stranded DNA endodeoxyribonuclease activity
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003684	damaged DNA binding
GO:0005515	protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000724	double-strand break repair via homologous recombination
GO:0000737	DNA catabolic process, endonucleolytic
GO:0001835	blastocyst hatching
GO:0007067	mitotic nuclear division
GO:0007126	meiotic nuclear division
GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing
GO:0031572	G2 DNA damage checkpoint