Version 5.4
| Mus musculus Gene: Lama3 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-128959.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Lama3 | ||||||||
| Gene Name | laminin, alpha 3 | ||||||||
| Synonyms | [a]3B; Lama3B | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000024421 | ||||||||
| Encoded Proteins |
laminin, alpha 3
laminin, alpha 3
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000053747:
Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 subunit of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 18:12333819-12583013 | ||||||||
| Strand | Forward strand | ||||||||
| Band | A1 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Extracellular matrix organization pathway
Laminin interactions pathway
Non-integrin membrane-ECM interactions pathway
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| KEGG |
ECM-receptor interaction pathway
Small cell lung cancer pathway
Focal adhesion pathway
Pathways in cancer pathway
Amoebiasis pathway
Toxoplasmosis pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
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| REACTOME |
Anchoring fibril formation pathway
Assembly of collagen fibrils and other multimeric structures pathway
Type I hemidesmosome assembly pathway
Cell-Cell communication pathway
Extracellular matrix organization pathway
Cell junction organization pathway
Degradation of the extracellular matrix pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Laminin interactions pathway
Collagen formation pathway
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| KEGG |
ECM-receptor interaction pathway
Small cell lung cancer pathway
Focal adhesion pathway
Pathways in cancer pathway
Amoebiasis pathway
Toxoplasmosis pathway
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| INOH | |||||||||
| PID NCI |
Syndecan-2-mediated signaling events
Beta1 integrin cell surface interactions
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Alpha6 beta4 integrin-ligand interactions
Syndecan-4-mediated signaling events
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | |||||||||
| RefSeq | NM_010680 XM_006525685 XM_006525686 XM_006525688 XM_006525689 XM_006525690 XM_006525691 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS50222 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | |||||||||
| MGI Symbol | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||