InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Met

Summary

InnateDB Gene

IDBG-129003.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Met

Gene Name

met proto-oncogene

Synonyms

AI838057; c-Met; HGF; HGFR; Par4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000009376

Encoded Proteins

IDBP-129005

met proto-oncogene

IDBP-249635

met proto-oncogene

IDBP-249637

met proto-oncogene

IDBP-538713

met proto-oncogene

IDBP-534485

met proto-oncogene

IDBP-533177

met proto-oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105976:
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:17463800-17573980

Strand

Forward strand

Band

Transcripts

ENSMUST00000080469	ENSMUSP00000079324
ENSMUST00000115443	ENSMUSP00000111103
ENSMUST00000115442	ENSMUSP00000111102
ENSMUST00000140070	ENSMUSP00000117856
ENSMUST00000145473
ENSMUST00000152802	ENSMUSP00000118755
ENSMUST00000148903	ENSMUSP00000121923

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005008	hepatocyte growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001889	liver development
GO:0001890	placenta development
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275	multicellular organismal development
GO:0007420	brain development
GO:0007517	muscle organ development
GO:0007519	skeletal muscle tissue development
GO:0010828	positive regulation of glucose transport
GO:0014812	muscle cell migration
GO:0014902	myotube differentiation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030534	adult behavior
GO:0042593	glucose homeostasis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050918	positive chemotaxis
GO:0051450	myoblast proliferation
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0071526	semaphorin-plexin signaling pathway
GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2001028	positive regulation of endothelial cell chemotaxis