Homo sapiens Gene: TMED10
Summary
InnateDB Gene IDBG-12915.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMED10
Gene Name transmembrane emp24-like trafficking protein 10 (yeast)
Synonyms p23; P24(DELTA); S31I125; S31III125; Tmp-21-I; TMP21;
Species Homo sapiens
Ensembl Gene ENSG00000170348
Encoded Proteins
transmembrane emp24-like trafficking protein 10 (yeast)
transmembrane emp24-like trafficking protein 10 (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]
This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex\'s gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer\'s disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:75131470-75176631
Strand Reverse strand
Band q24.3
Transcripts
ENST00000303575 ENSP00000303145
ENST00000556969
ENST00000557670
ENST00000555036
ENST00000555873 ENSP00000450726
ENST00000555085
ENST00000622441
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 31 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019905 syntaxin binding
GO:0032403 protein complex binding
Biological Process
GO:0001822 kidney development
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0007030 Golgi organization
GO:0034205 beta-amyloid formation
GO:0035459 cargo loading into vesicle
GO:0035964 COPI-coated vesicle budding
GO:0043279 response to alkaloid
GO:0045055 regulated secretory pathway
GO:0048199 vesicle targeting, to, from or within Golgi
GO:0048205 COPI coating of Golgi vesicle
GO:0048208 COPII vesicle coating
GO:0051259 protein oligomerization
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030137 COPI-coated vesicle
GO:0030140 trans-Golgi network transport vesicle
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042470 melanosome
GO:0042589 zymogen granule membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
GO:0070765 gamma-secretase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.593028 Hs.74137
RefSeq NM_006827
HUGO
OMIM
CCDS CCDS9840
HPRD 12013
IMGT
EMBL
GenPept
RNA Seq Atlas