Version 5.4
Mus musculus Gene: Prlr
Summary
InnateDB Gene IDBG-129218.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prlr
Gene Name prolactin receptor
Synonyms AI987712; Pr-1; Pr-3; Prlr-rs1
Species Mus musculus
Ensembl Gene ENSMUSG00000005268
Encoded Proteins
IDBP-535501
prolactin receptor
IDBP-541031
prolactin receptor
IDBP-533361
prolactin receptor
IDBP-540258
prolactin receptor
IDBP-541988
prolactin receptor
IDBP-541987
prolactin receptor
IDBP-535441
prolactin receptor
IDBP-538656
prolactin receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113494:
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:10177238-10349180
Strand Forward strand
Band A1
Transcripts
ENSMUST00000005400
ENSMUST00000145428
ENSMUST00000137867 ENSMUSP00000121935
ENSMUST00000124470 ENSMUSP00000122219
ENSMUST00000132361
ENSMUST00000138135
ENSMUST00000130720 ENSMUSP00000117084
ENSMUST00000148257 ENSMUSP00000118355
ENSMUST00000128450 ENSMUSP00000122209
ENSMUST00000128921 ENSMUSP00000121280
ENSMUST00000134410 ENSMUSP00000120417
ENSMUST00000127467 ENSMUSP00000116211
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004925 prolactin receptor activity
GO:0005515 protein binding
GO:0017046 peptide hormone binding
GO:0046872 metal ion binding
Biological Process
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity
GO:0007259 JAK-STAT cascade
GO:0007595 lactation
GO:0030155 regulation of cell adhesion
GO:0030856 regulation of epithelial cell differentiation
GO:0038161 prolactin signaling pathway
GO:0060644 mammary gland epithelial cell differentiation
GO:0060736 prostate gland growth
GO:0060749 mammary gland alveolus development
GO:0061180 mammary gland epithelium development
Cellular Component
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113494
View Gene Order
ENSBTAG00000025035
Not yet available
Pathways
NETPATH
REACTOME
REACT_198574
Nuclear signaling by ERBB4 pathway
REACT_198561
Prolactin receptor signaling pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_198614
Growth hormone receptor signaling pathway
REACT_188257
Signal Transduction pathway
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_56
Prolactin pathway
REACTOME
REACT_111133
Growth hormone receptor signaling pathway
REACT_115697
Prolactin receptor signaling pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
erbb4_pathway
ErbB4 signaling events
ptp1bpathway
Signaling events mediated by PTP1B
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.10516 Mm.395196 Mm.442446
RefSeq NM_001253781 NM_001253782 NM_011169 XM_006520034 XM_006520035 XM_006520036 XM_006520037 XM_006520038
OMIM
CCDS CCDS27377 CCDS56975 CCDS56976
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca