Version 5.4
Mus musculus Gene: Nlrc3
Summary
InnateDB Gene IDBG-129350.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nlrc3
Gene Name NLR family, CARD domain containing 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000049871
Encoded Proteins
IDBP-706921
IDBP-707647
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22863753
Nlrc3 inhibits Toll-like receptor (TLR)-dependent activation of NF-kB by interacting with the TLR signalling adaptor Traf6 to attenuate ubiquitination of Traf6 and activation of NF-kB.
InnateDB Annotation from Orthologs
Summary
PMID 22863753
[Homo sapiens] NLRC3 inhibits Toll-like receptor (TLR)-dependent activation of NF-kB by interacting with the TLR signalling adaptor TRAF6 to attenuate ubiquitination of TRAF6 and activation of NF-kB. (Demonstrated in mouse)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167984:
The protein encoded by this gene is a cytosolic regulator of innate immunity. The encoded protein contains several leucine-rich repeat domains and may be involved in regulating T-cell activation. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:3945007-3976632
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000096308
ENSMUST00000163478
ENSMUST00000180200 ENSMUSP00000137325
ENSMUST00000177551 ENSMUSP00000137628
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0031396 regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032496 response to lipopolysaccharide
GO:0042110 T cell activation
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167984
View Gene Order
ENSBTAG00000004505
Not yet available
Cross-References
SwissProt Q5DU56
TrEMBL
UniProt Splice Variant
Entrez Gene 268857
UniGene Mm.215994
RefSeq NM_175547 XM_006522151 NM_001081280
OMIM
CCDS CCDS70677 CCDS49747
HPRD
IMGT
MGI ID MGI:2444070
MGI Symbol Nlrc3
EMBL AK079766 AK084199 AK171971 AK220314 BC130223
GenPept AAI30224 BAC37747 BAC39136 BAD90390 BAE42752
RNA Seq Atlas 268857

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca