InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hdac6

Summary

InnateDB Gene

IDBG-129835.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hdac6

Gene Name

histone deacetylase 6

Synonyms

Hd6; Hdac5; mHDA2; Sfc6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031161

Encoded Proteins

IDBP-129837

histone deacetylase 6

IDBP-249171

histone deacetylase 6

IDBP-532355

histone deacetylase 6

IDBP-540543

histone deacetylase 6

IDBP-541090

histone deacetylase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000094631:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:7930120-7947889

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000033501	ENSMUSP00000033501
ENSMUST00000115642	ENSMUSP00000111306
ENSMUST00000137499
ENSMUST00000145675	ENSMUSP00000121653
ENSMUST00000153788
ENSMUST00000151916
ENSMUST00000156127
ENSMUST00000154200
ENSMUST00000133349	ENSMUSP00000120348
ENSMUST00000154244	ENSMUSP00000123482

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 143 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	143 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0031593	polyubiquitin binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0042826	histone deacetylase binding
GO:0042903	tubulin deacetylase activity
GO:0043014	alpha-tubulin binding
GO:0043130	ubiquitin binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048156	tau protein binding
GO:0048487	beta-tubulin binding
GO:0051879	Hsp90 protein binding
GO:0070840	dynein complex binding
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000209	protein polyubiquitination
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006476	protein deacetylation
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0006886	intracellular protein transport
GO:0007026	negative regulation of microtubule depolymerization
GO:0008152	metabolic process
GO:0009636	response to toxic substance
GO:0009967	positive regulation of signal transduction
GO:0010033	response to organic substance
GO:0010469	regulation of receptor activity
GO:0010634	positive regulation of epithelial cell migration
GO:0010870	positive regulation of receptor biosynthetic process
GO:0016236	macroautophagy
GO:0016575	histone deacetylation
GO:0032418	lysosome localization
GO:0034983	peptidyl-lysine deacetylation
GO:0035967	cellular response to topologically incorrect protein
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043241	protein complex disassembly
GO:0043242	negative regulation of protein complex disassembly
GO:0045861	negative regulation of proteolysis
GO:0051788	response to misfolded protein
GO:0070201	regulation of establishment of protein localization
GO:0070301	cellular response to hydrogen peroxide
GO:0070842	aggresome assembly
GO:0070845	polyubiquitinated misfolded protein transport
GO:0070846	Hsp90 deacetylation
GO:0070848	response to growth factor
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0071218	cellular response to misfolded protein
GO:0090035	positive regulation of chaperone-mediated protein complex assembly
GO:0090042	tubulin deacetylation
GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0005881	cytoplasmic microtubule
GO:0005901	caveola
GO:0016234	inclusion body
GO:0016235	aggresome
GO:0030286	dynein complex
GO:0030424	axon
GO:0030425	dendrite
GO:0031252	cell leading edge
GO:0043204	perikaryon
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm