InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gata1

Summary

InnateDB Gene

IDBG-129965.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gata1

Gene Name

GATA binding protein 1

Synonyms

eryf1; Gata-1; Gf-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031162

Encoded Proteins

IDBP-129967

GATA binding protein 1

IDBP-542285

GATA binding protein 1

IDBP-542503

GATA binding protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102145:
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:7959260-7978071

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000033502	ENSMUSP00000033502
ENSMUST00000125418	ENSMUSP00000118052
ENSMUST00000128449	ENSMUSP00000123620

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	47 [view]
Protein-Protein	38 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001085	RNA polymerase II transcription factor binding
GO:0001158	enhancer sequence-specific DNA binding
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008301	DNA binding, bending
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007267	cell-cell signaling
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0010559	regulation of glycoprotein biosynthetic process
GO:0010724	regulation of definitive erythrocyte differentiation
GO:0030099	myeloid cell differentiation
GO:0030218	erythrocyte differentiation
GO:0030219	megakaryocyte differentiation
GO:0030220	platelet formation
GO:0030221	basophil differentiation
GO:0030222	eosinophil differentiation
GO:0030502	negative regulation of bone mineralization
GO:0033690	positive regulation of osteoblast proliferation
GO:0035162	embryonic hemopoiesis
GO:0035854	eosinophil fate commitment
GO:0043066	negative regulation of apoptotic process
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048468	cell development
GO:0048821	erythrocyte development
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0070527	platelet aggregation
GO:0071733	transcriptional activation by promoter-enhancer looping
GO:0097028	dendritic cell differentiation
GO:0097067	cellular response to thyroid hormone stimulus
GO:2000678	negative regulation of transcription regulatory region DNA binding
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand