Version 5.4
| Mus musculus Gene: Ebp | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-130286.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Ebp | ||||||||
| Gene Name | phenylalkylamine Ca2+ antagonist (emopamil) binding protein | ||||||||
| Synonyms | AI255399; mSI; Pabp; Td | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000031168 | ||||||||
| Encoded Proteins |
phenylalkylamine Ca2+ antagonist (emopamil) binding protein
phenylalkylamine Ca2+ antagonist (emopamil) binding protein
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147155:
The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008] The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome). [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome X:8185329-8193512 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | A1.1 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME |
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Cholesterol biosynthesis pathway
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| KEGG |
Steroid biosynthesis pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Cholesterol biosynthesis pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
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| KEGG |
Steroid biosynthesis pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | P70245 | ||||||||
| TrEMBL | A2AC29 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 13595 | ||||||||
| UniGene | Mm.27183 Mm.392069 | ||||||||
| RefSeq | NM_007898 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS29989 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:107822 | ||||||||
| MGI Symbol | Ebp | ||||||||
| EMBL | AK012266 AK027977 AL663032 BC004620 BC004703 X97755 | ||||||||
| GenPept | AAH04620 AAH04703 BAB28129 BAC25686 CAA66350 | ||||||||
| RNA Seq Atlas | 13595 | ||||||||