Mus musculus Gene: Rgs17
Summary
InnateDB Gene IDBG-130367.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rgs17
Gene Name regulator of G-protein signaling 17
Synonyms 6430507P11Rik; Rgsz2
Species Mus musculus
Ensembl Gene ENSMUSG00000019775
Encoded Proteins
regulator of G-protein signaling 17
regulator of G-protein signaling 17
regulator of G-protein signaling 17
regulator of G-protein signaling 17
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091844:
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:5825663-5922400
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000019909 ENSMUSP00000019909
ENSMUST00000064225 ENSMUSP00000065825
ENSMUST00000117676 ENSMUSP00000113519
ENSMUST00000131996 ENSMUSP00000116291
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Signaling by GPCR pathway
G alpha (z) signalling events pathway
Signal Transduction pathway
KEGG
INOH
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
G alpha (z) signalling events pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
KEGG
INOH
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.394911 Mm.44606
RefSeq NM_001161822 NM_019958 XM_006512457
OMIM
CCDS CCDS56685 CCDS56686
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas