Version 5.4
Mus musculus Gene: Adam17
Summary
InnateDB Gene IDBG-130508.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Adam17
Gene Name a disintegrin and metallopeptidase domain 17
Synonyms CD156b; Tace
Species Mus musculus
Ensembl Gene ENSMUSG00000052593
Encoded Proteins
IDBP-130510
a disintegrin and metallopeptidase domain 17
IDBP-130512
a disintegrin and metallopeptidase domain 17
IDBP-712896
IDBP-713508
IDBP-710239
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25461404
Adam17 affects sensitivity to interleukin-1 by changing the balance between Il1r1 and Il1r2 receptors.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151694:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:21323509-21373632
Strand Reverse strand
Band A1.3
Transcripts
ENSMUST00000101551 ENSMUSP00000099087
ENSMUST00000064536 ENSMUSP00000067953
ENSMUST00000127974 ENSMUSP00000136677
ENSMUST00000145118 ENSMUSP00000136407
ENSMUST00000141799
ENSMUST00000155115
ENSMUST00000132339
ENSMUST00000142092 ENSMUSP00000136255
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005112 Notch binding
GO:0005138 interleukin-6 receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0017124 SH3 domain binding
GO:0030165 PDZ domain binding
Biological Process
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0002467 germinal center formation
GO:0006508 proteolysis
GO:0006509 membrane protein ectodomain proteolysis
GO:0007155 cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0007229 integrin-mediated signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0010820 positive regulation of T cell chemotaxis
GO:0030183 B cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031659 positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032496 response to lipopolysaccharide
GO:0032717 negative regulation of interleukin-8 production
GO:0032722 positive regulation of chemokine production
GO:0033025 regulation of mast cell apoptotic process
GO:0033077 T cell differentiation in thymus
GO:0033627 cell adhesion mediated by integrin
GO:0035313 wound healing, spreading of epidermal cells
GO:0035625 epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0042493 response to drug
GO:0045087 innate immune response (InnateDB)
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0048536 spleen development
GO:0048870 cell motility
GO:0051088 PMA-inducible membrane protein ectodomain proteolysis
GO:0051272 positive regulation of cellular component movement
GO:0055099 response to high density lipoprotein particle stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0009986 cell surface
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0032587 ruffle membrane
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000151694
View Gene Order
ENSBTAG00000001141
Not yet available
Pathways
NETPATH
REACTOME
REACT_258521
Apoptosis pathway
REACT_198574
Nuclear signaling by ERBB4 pathway
REACT_189085
Disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_206066
Extracellular matrix organization pathway
REACT_233316
Hedgehog ligand biogenesis pathway
REACT_256171
TNF signaling pathway
REACT_248271
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_242976
Signaling by EGFR pathway
REACT_257735
Death Receptor Signalling pathway
REACT_247063
Release of Hh-Np from the secreting cell pathway
REACT_248921
Signalling by NGF pathway
REACT_259850
Extrinsic Pathway for Apoptosis pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_198614
Growth hormone receptor signaling pathway
REACT_218614
Regulated proteolysis of p75NTR pathway
REACT_188257
Signal Transduction pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_199055
Collagen degradation pathway
KEGG
mmu04330
Notch signaling pathway pathway
mmu05010
Alzheimer's disease pathway
INOH
INOH website
Notch signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_3
Notch pathway
NetPath_4
EGFR1 pathway
REACTOME
REACT_111133
Growth hormone receptor signaling pathway
REACT_13443
Regulated proteolysis of p75NTR pathway
REACT_9417
Signaling by EGFR pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_118614
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_150401
Collagen degradation pathway
REACT_1432
TNF signaling pathway
REACT_160089
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
REACT_160106
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_228190
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_11061
Signalling by NGF pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_118779
Extracellular matrix organization pathway
REACT_1059
Extrinsic Pathway for Apoptosis pathway
REACT_228239
Release of Hh-Np from the secreting cell pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_228111
Hedgehog ligand biogenesis pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_1619
Death Receptor Signalling pathway
KEGG
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa04330
Notch signaling pathway pathway
hsa05010
Alzheimer's disease pathway
INOH
INOH website
Notch signaling pathway pathway
PID NCI
erbb4_pathway
ErbB4 signaling events
tnfpathway
TNF receptor signaling pathway
p75ntrpathway
p75(NTR)-mediated signaling
Cross-References
SwissProt
TrEMBL J3QNB3
UniProt Splice Variant
Entrez Gene 11491
UniGene Mm.27681
RefSeq NM_001277266 NM_001291871 NM_009615
OMIM
CCDS CCDS25836 CCDS70376
HPRD
IMGT
MGI ID MGI:1096335
MGI Symbol Adam17
EMBL AC140457 AC156032
GenPept
RNA Seq Atlas 11491

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca