Version 5.4
Mus musculus Gene: Lyst
Summary
InnateDB Gene IDBG-130720.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lyst
Gene Name lysosomal trafficking regulator
Synonyms beige; bg; D13Sfk13
Species Mus musculus
Ensembl Gene ENSMUSG00000019726
Encoded Proteins
IDBP-259990
lysosomal trafficking regulator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143669:
This gene is thought to encode a protein that regulates intracellular protein trafficking to and from the lysosome. Mutations in this gene are associated with Chediak-Higashi syndrome, a rare lysosomal storage disorder. Alternatively spliced transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a protein that regulates intracellular protein trafficking in endosomes, and may be involved in pigmentation. Mutations in this gene are associated with Chediak-Higashi syndrome, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants, though the full-length nature of some of these variants has not been determined. [provided by RefSeq, Apr 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:13590409-13777440
Strand Forward strand
Band A1
Transcripts
ENSMUST00000110559 ENSMUSP00000106188
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0002446 neutrophil mediated immunity
GO:0002456 T cell mediated immunity
GO:0006644 phospholipid metabolic process
GO:0007017 microtubule-based process
GO:0007040 lysosome organization
GO:0007596 blood coagulation
GO:0030595 leukocyte chemotaxis
GO:0032438 melanosome organization
GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway
GO:0032816 positive regulation of natural killer cell activation
GO:0033299 secretion of lysosomal enzymes
GO:0033364 mast cell secretory granule organization
GO:0042267 natural killer cell mediated cytotoxicity
GO:0042493 response to drug
GO:0042742 defense response to bacterium
GO:0042832 defense response to protozoan
GO:0043473 pigmentation
GO:0048753 pigment granule organization
GO:0051607 defense response to virus
GO:0055091 phospholipid homeostasis
Cellular Component
GO:0005829 cytosol
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000143669
View Gene Order
ENSBTAG00000016804
Not yet available
Cross-References
SwissProt
TrEMBL G5E8Q0 Q3U4C2 Q8BN38 Q8BQ04
UniProt Splice Variant
Entrez Gene 17101
UniGene Mm.342337
RefSeq NM_010748 XM_006516563
OMIM
CCDS CCDS36597
HPRD
IMGT
MGI ID MGI:107448
MGI Symbol Lyst
EMBL AC121910 AC171200 AK051786 AK089635 AK154317 CH466561 CT010431
GenPept BAC34768 BAC40935 BAE32510 EDL32764
RNA Seq Atlas 17101

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca