Version 5.4
Homo sapiens Gene: BNIP3L
Summary
InnateDB Gene IDBG-13074.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BNIP3L
Gene Name BCL2/adenovirus E1B 19kDa interacting protein 3-like
Synonyms BNIP3a; NIX
Species Homo sapiens
Ensembl Gene ENSG00000104765
Encoded Proteins
IDBP-13078
BCL2/adenovirus E1B 19kDa interacting protein 3-like
IDBP-478468
BCL2/adenovirus E1B 19kDa interacting protein 3-like
IDBP-479098
BCL2/adenovirus E1B 19kDa interacting protein 3-like
IDBP-477345
BCL2/adenovirus E1B 19kDa interacting protein 3-like
IDBP-473962
BCL2/adenovirus E1B 19kDa interacting protein 3-like
IDBP-476607
BCL2/adenovirus E1B 19kDa interacting protein 3-like
IDBP-813082
BCL2/adenovirus E1B 19kDa interacting protein 3-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26253785
[Mus musculus] Mitophagy-inducing proteins Bnip3 and Bnip3l play a regulatory role in the generation of robust natural killer cell memory.
Entrez Gene
Summary This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein counteracts the apoptotic inducer BNIP3 and may play a role in tumor suppression. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:26382898-26505636
Strand Forward strand
Band p21.2
Transcripts
ENST00000380629 ENSP00000370003
ENST00000520077 ENSP00000428919
ENST00000523949 ENSP00000429171
ENST00000523515 ENSP00000429698
ENST00000520409 ENSP00000428597
ENST00000518611 ENSP00000429851
ENST00000521254
ENST00000620910 ENSP00000479522
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 41 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005521 lamin binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0016032 viral process
GO:0035694 mitochondrial protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0051607 defense response to virus
GO:0097345 mitochondrial outer membrane permeabilization
Cellular Component
GO:0005635 nuclear envelope
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0031224 intrinsic component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022051
View Gene Order
ENSBTAG00000021307
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
p53downstreampathway
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.718221
RefSeq NM_004331 XM_005273617
HUGO
OMIM
CCDS CCDS6050
HPRD 07288
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca