Homo sapiens Gene: BNIP3L
Summary
InnateDB Gene IDBG-13074.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BNIP3L
Gene Name BCL2/adenovirus E1B 19kDa interacting protein 3-like
Synonyms BNIP3a; NIX;
Species Homo sapiens
Ensembl Gene ENSG00000104765
Encoded Proteins
BCL2/adenovirus E1B 19kDa interacting protein 3-like
BCL2/adenovirus E1B 19kDa interacting protein 3-like
BCL2/adenovirus E1B 19kDa interacting protein 3-like
BCL2/adenovirus E1B 19kDa interacting protein 3-like
BCL2/adenovirus E1B 19kDa interacting protein 3-like
BCL2/adenovirus E1B 19kDa interacting protein 3-like
BCL2/adenovirus E1B 19kDa interacting protein 3-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Mitophagy-inducing proteins Bnip3 and Bnip3l play a regulatory role in the generation of robust natural killer cell memory.
Entrez Gene
Summary This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein counteracts the apoptotic inducer BNIP3 and may play a role in tumor suppression. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:26382898-26505636
Strand Forward strand
Band p21.2
Transcripts
ENST00000380629 ENSP00000370003
ENST00000520077 ENSP00000428919
ENST00000523949 ENSP00000429171
ENST00000523515 ENSP00000429698
ENST00000520409 ENSP00000428597
ENST00000518611 ENSP00000429851
ENST00000521254
ENST00000620910 ENSP00000479522
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
Experimentally validated
Total 44 [view]
Protein-Protein 41 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005521 lamin binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0016032 viral process
GO:0035694 mitochondrial protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0051607 defense response to virus
GO:0097345 mitochondrial outer membrane permeabilization
Cellular Component
GO:0005635 nuclear envelope
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0031224 intrinsic component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Direct p53 effectors
Cross-References
SwissProt
TrEMBL Q9H3K3
UniProt Splice Variant
Entrez Gene 665
UniGene
RefSeq NM_004331 XM_005273617
HUGO HGNC:1085
OMIM 605368
CCDS CCDS6050
HPRD
IMGT
EMBL AF060922
GenPept AAG43134
RNA Seq Atlas 665