Version 5.4
Mus musculus Gene: Ank
Summary
InnateDB Gene IDBG-131382.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ank
Gene Name progressive ankylosis
Synonyms ank; Ankh; D15Ertd221e; mKIAA1581
Species Mus musculus
Ensembl Gene ENSMUSG00000022265
Encoded Proteins
IDBP-131384
progressive ankylosis
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154122:
This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:27466677-27594909
Strand Forward strand
Band B1
Transcripts
ENSMUST00000022875 ENSMUSP00000022875
ENSMUST00000134004
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005315 inorganic phosphate transmembrane transporter activity
GO:0015114 phosphate ion transmembrane transporter activity
GO:0030504 inorganic diphosphate transmembrane transporter activity
Biological Process
GO:0030500 regulation of bone mineralization
GO:0030505 inorganic diphosphate transport
GO:0035435 phosphate ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154122
View Gene Order
ENSBTAG00000013391
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9JHZ2
TrEMBL Q3UG85
UniProt Splice Variant
Entrez Gene 11732
UniGene Mm.265264 Mm.473352
RefSeq NM_020332
OMIM
CCDS CCDS27402
HPRD
IMGT
MGI ID MGI:3045421
MGI Symbol Ank
EMBL AF001532 AF001533 AF274752 AK148070 BC054379 CH466541 DQ832285
GenPept AAB65653 AAB65654 AAF88038 AAH54379 ABI30219 BAE28324 EDL08900
RNA Seq Atlas 11732

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca