InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kat5

Summary

InnateDB Gene

IDBG-132192.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kat5

Gene Name

K(lysine) acetyltransferase 5

Synonyms

AI839539; CPLA2; Htatip; Htatip1; PLIP; Tip55; Tip60

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024926

Encoded Proteins

IDBP-253446

K(lysine) acetyltransferase 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172977:
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:5603017-5610094

Strand

Reverse strand

Band

Transcripts

ENSMUST00000113641

ENSMUSP00000109271

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 175 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	17 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	175 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0032403	protein complex binding
GO:0046872	metal ion binding
GO:0070491	repressing transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006302	double-strand break repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0010212	response to ionizing radiation
GO:0016573	histone acetylation
GO:0032703	negative regulation of interleukin-2 production
GO:0040008	regulation of growth
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0000785	chromatin
GO:0000812	Swr1 complex
GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0032777	Piccolo NuA4 histone acetyltransferase complex
GO:0035267	NuA4 histone acetyltransferase complex
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm