InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Katna1

Summary

InnateDB Gene

IDBG-132542.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Katna1

Gene Name

katanin p60 (ATPase-containing) subunit A1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019794

Encoded Proteins

IDBP-132544

katanin p60 (ATPase-containing) subunit A1

IDBP-627776

katanin p60 (ATPase-containing) subunit A1

IDBP-627777

katanin p60 (ATPase-containing) subunit A1

IDBP-627778

katanin p60 (ATPase-containing) subunit A1

IDBP-627779

katanin p60 (ATPase-containing) subunit A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186625:
Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:7726000-7763150

Strand

Forward strand

Band

Transcripts

ENSMUST00000019929	ENSMUSP00000019929
ENSMUST00000173400	ENSMUSP00000133588
ENSMUST00000172400
ENSMUST00000174007	ENSMUSP00000133321
ENSMUST00000173511	ENSMUSP00000134254
ENSMUST00000165806	ENSMUSP00000132514

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0008568	microtubule-severing ATPase activity
GO:0009378	four-way junction helicase activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0045502	dynein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001578	microtubule bundle formation
GO:0001764	neuron migration
GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0007126	meiotic nuclear division
GO:0008104	protein localization
GO:0010977	negative regulation of neuron projection development
GO:0031122	cytoplasmic microtubule organization
GO:0051013	microtubule severing
GO:0051329	interphase of mitotic cell cycle

Cellular Component

GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005811	lipid particle
GO:0005813	centrosome
GO:0005819	spindle
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0030424	axon
GO:0030426	growth cone
GO:0030496	midbody
GO:0043025	neuronal cell body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000186625

View Gene Order

ENSBTAG00000032024

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

lis1pathway

Lissencephaly gene (LIS1) in neuronal migration and development

Cross-References

SwissProt

TrEMBL

E9QKG2

UniProt Splice Variant

Entrez Gene

23924

UniGene

Mm.28127 Mm.482623

RefSeq

XM_006512738 NM_011835

OMIM

CCDS

CCDS23689

HPRD

IMGT

MGI ID

MGI:1344353

MGI Symbol

Katna1

EMBL

AC156391

GenPept

RNA Seq Atlas

23924