InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cct5

Summary

InnateDB Gene

IDBG-132917.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cct5

Gene Name

chaperonin containing Tcp1, subunit 5 (epsilon)

Synonyms

Ccte; mKIAA0098; TCPE

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022234

Encoded Proteins

IDBP-132919

chaperonin containing Tcp1, subunit 5 (epsilon)

IDBP-540445

chaperonin containing Tcp1, subunit 5 (epsilon)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150753:
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. In addition, three pseudogenes of this gene have been identified. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:31590800-31601847

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022842	ENSMUSP00000022842
ENSMUST00000160174
ENSMUST00000159449
ENSMUST00000161266	ENSMUSP00000125566
ENSMUST00000159121

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 103 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	103 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0031681	G-protein beta-subunit binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0007339	binding of sperm to zona pellucida
GO:0009615	response to virus
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0002199	zona pellucida receptor complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005832	chaperonin-containing T-complex
GO:0005874	microtubule
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome