Version 5.4
Mus musculus Gene: Slc26a3
Summary
InnateDB Gene IDBG-133142.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc26a3
Gene Name solute carrier family 26, member 3
Synonyms 9030623B18Rik; 9130013M11Rik; AV376035; Dra
Species Mus musculus
Ensembl Gene ENSMUSG00000001225
Encoded Proteins
IDBP-133144
solute carrier family 26, member 3
IDBP-259364
solute carrier family 26, member 3
IDBP-262741
solute carrier family 26, member 3
IDBP-624328
solute carrier family 26, member 3
IDBP-624329
solute carrier family 26, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the solute carrier/sulfate transporter family. The encoded protein is predominantly expressed in the intestine where it is essential for chloride absorption. Disruption of this gene results in chloride-rich diarrhea and compensatory up-regulation of ion-absorbing transporters. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:31390871-31473917
Strand Forward strand
Band A2
Transcripts
ENSMUST00000001254 ENSMUSP00000001254
ENSMUST00000110854 ENSMUSP00000106478
ENSMUST00000109275 ENSMUSP00000104898
ENSMUST00000167432 ENSMUSP00000130676
ENSMUST00000171616 ENSMUSP00000128722
ENSMUST00000168209
ENSMUST00000165816
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0015301 anion:anion antiporter activity
Biological Process
GO:0006820 anion transport
GO:0006821 chloride transport
GO:0008272 sulfate transport
GO:0015701 bicarbonate transport
GO:0048240 sperm capacitation
GO:0051454 intracellular pH elevation
GO:0055085 transmembrane transport
GO:0060081 membrane hyperpolarization
GO:0071320 cellular response to cAMP
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0097225 sperm midpiece
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000091138
View Gene Order
ENSBTAG00000015547
Not yet available
Pathways
NETPATH
REACTOME
REACT_258881
Multifunctional anion exchangers pathway
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_251788
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
mmu04972
Pancreatic secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_19357
Multifunctional anion exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa04972
Pancreatic secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.283281 Mm.490454
RefSeq NM_021353
OMIM
CCDS CCDS25863
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca