InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cask

Summary

InnateDB Gene

IDBG-133241.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cask

Gene Name

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Synonyms

DXPri1; DXRib1; LIN-2; mLin-2; Pals3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031012

Encoded Proteins

IDBP-133243

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

IDBP-249623

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

IDBP-249625

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

IDBP-249627

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

IDBP-540991

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

IDBP-539861

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

IDBP-537399

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

IDBP-532661

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

IDBP-542416

calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147044:
This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:13517080-13851367

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000033321	ENSMUSP00000033321
ENSMUST00000115438	ENSMUSP00000111098
ENSMUST00000115436	ENSMUSP00000111096
ENSMUST00000115435	ENSMUSP00000111095
ENSMUST00000156096	ENSMUSP00000120299
ENSMUST00000128095	ENSMUSP00000122664
ENSMUST00000139735	ENSMUSP00000117862
ENSMUST00000152358
ENSMUST00000128012	ENSMUSP00000114187
ENSMUST00000124710	ENSMUSP00000119584
ENSMUST00000132240
ENSMUST00000155989

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042043	neurexin family protein binding

Biological Process

GO:0001953	negative regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0010839	negative regulation of keratinocyte proliferation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0061045	negative regulation of wound healing
GO:0070509	calcium ion import
GO:0090280	positive regulation of calcium ion import
GO:0090288	negative regulation of cellular response to growth factor stimulus

Cellular Component

GO:0005604	basement membrane
GO:0005634	nucleus
GO:0005652	nuclear lamina
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016363	nuclear matrix
GO:0045202	synapse