InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Map3k2

Summary

InnateDB Gene

IDBG-133552.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map3k2

Gene Name

mitogen-activated protein kinase kinase kinase 2

Synonyms

9630061B06Rik; AI585793; Mekk2; Mekk2b

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024383

Encoded Proteins

IDBP-133556

mitogen-activated protein kinase kinase kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169967:
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:32163089-32236751

Strand

Forward strand

Band

Transcripts

ENSMUST00000096575

ENSMUSP00000094326

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0006468	protein phosphorylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0071260	cellular response to mechanical stimulus