InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Epm2a

Summary

InnateDB Gene

IDBG-133616.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epm2a

Gene Name

epilepsy, progressive myoclonic epilepsy, type 2 gene alpha

Synonyms

TG-B; Tg(TcraK,TcrbK)TG-BFlv

Species

Mus musculus

Ensembl Gene

ENSMUSG00000055493

Encoded Proteins

IDBP-133618

epilepsy, progressive myoclonic epilepsy, type 2 gene alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112425:
This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:11343404-11459644

Strand

Forward strand

Band

Transcripts

ENSMUST00000069106	ENSMUSP00000066050
ENSMUST00000161438

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0019203	carbohydrate phosphatase activity
GO:0030246	carbohydrate binding
GO:2001070	starch binding

Biological Process

GO:0005977	glycogen metabolic process
GO:0006470	protein dephosphorylation
GO:0006914	autophagy
GO:0007399	nervous system development
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0046855	inositol phosphate dephosphorylation
GO:0046959	habituation