Version 5.4
Mus musculus Gene: Prdm14
Summary
InnateDB Gene IDBG-133954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prdm14
Gene Name PR domain containing 14
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000042414
Encoded Proteins
IDBP-133956
PR domain containing 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147596:
This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:13113457-13127163
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000047577 ENSMUSP00000044245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001708 cell fate specification
GO:0001827 inner cell mass cell fate commitment
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007281 germ cell development
GO:0009566 fertilization
GO:0010468 regulation of gene expression
GO:0030718 germ-line stem cell maintenance
GO:0034972 histone H3-R26 methylation
GO:0040029 regulation of gene expression, epigenetic
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0044030 regulation of DNA methylation
GO:0048873 homeostasis of number of cells within a tissue
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000147596
View Gene Order
ENSBTAG00000000060
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_200812
Transcriptional regulation of pluripotent stem cells pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt E9Q3T6
TrEMBL
UniProt Splice Variant
Entrez Gene 383491
UniGene Mm.309380
RefSeq NM_001081209
OMIM
CCDS CCDS48221
HPRD
IMGT
MGI ID MGI:3588194
MGI Symbol Prdm14
EMBL AC091248 AK141218
GenPept BAE24596
RNA Seq Atlas 383491

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca