InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mtmr2

Summary

InnateDB Gene

IDBG-134064.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtmr2

Gene Name

myotubularin related protein 2

Synonyms

6030445P13Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031918

Encoded Proteins

IDBP-134066

myotubularin related protein 2

IDBP-536096

myotubularin related protein 2

IDBP-535828

myotubularin related protein 2

IDBP-542479

myotubularin related protein 2

IDBP-542477

myotubularin related protein 2

IDBP-533946

myotubularin related protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000087053:
This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:13748410-13806481

Strand

Forward strand

Band

Transcripts

ENSMUST00000034396	ENSMUSP00000034396
ENSMUST00000155679	ENSMUSP00000115906
ENSMUST00000136735
ENSMUST00000134674	ENSMUSP00000121933
ENSMUST00000156801	ENSMUSP00000117332
ENSMUST00000134530	ENSMUSP00000121223
ENSMUST00000152532	ENSMUSP00000114509
ENSMUST00000143002
ENSMUST00000146901

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0042803	protein homodimerization activity
GO:0052866	phosphatidylinositol phosphate phosphatase activity

Biological Process

GO:0002091	negative regulation of receptor internalization
GO:0016311	dephosphorylation
GO:0031642	negative regulation of myelination
GO:0032288	myelin assembly
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0045806	negative regulation of endocytosis
GO:0046488	phosphatidylinositol metabolic process
GO:0046855	inositol phosphate dephosphorylation
GO:0046856	phosphatidylinositol dephosphorylation
GO:0048666	neuron development
GO:0051262	protein tetramerization
GO:0090394	negative regulation of excitatory postsynaptic membrane potential
GO:0097062	dendritic spine maintenance
GO:2000643	positive regulation of early endosome to late endosome transport
GO:2000645	negative regulation of receptor catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005774	vacuolar membrane
GO:0005829	cytosol
GO:0008021	synaptic vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0031901	early endosome membrane
GO:0043197	dendritic spine
GO:0097060	synaptic membrane
GO:0097481	neuronal postsynaptic density