Mus musculus Gene: Crot
Summary
InnateDB Gene IDBG-134507.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Crot
Gene Name carnitine O-octanoyltransferase
Synonyms 1200003H03Rik;
Species Mus musculus
Ensembl Gene ENSMUSG00000003623
Encoded Proteins
carnitine O-octanoyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005469:
This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:8966033-8997324
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000003720 ENSMUSP00000003720
ENSMUST00000146115
ENSMUST00000157024
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0008458 carnitine O-octanoyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0009437 carnitine metabolic process
GO:0015908 fatty acid transport
GO:0015936 coenzyme A metabolic process
GO:0051791 medium-chain fatty acid metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Beta-oxidation of pristanoyl-CoA pathway
Peroxisomal lipid metabolism pathway
KEGG
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Beta-oxidation of pristanoyl-CoA pathway
Peroxisomal lipid metabolism pathway
Metabolism pathway
KEGG
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28197
RefSeq NM_023733
OMIM
CCDS CCDS19087
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas