InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Lamp1

Summary

InnateDB Gene

IDBG-134722.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lamp1

Gene Name

lysosomal-associated membrane protein 1

Synonyms

AI196048; CD107a; Lamp-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031447

Encoded Proteins

IDBP-134724

lysosomal-associated membrane protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185896:
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:13159135-13175338

Strand

Forward strand

Band

A1.1

Transcripts

ENSMUST00000033824

ENSMUSP00000033824

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006914	autophagy
GO:0007283	spermatogenesis
GO:0008626	granzyme-mediated apoptotic signaling pathway
GO:0043323	positive regulation of natural killer cell degranulation
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0048102	autophagic cell death
GO:0050821	protein stabilization
GO:0072594	establishment of protein localization to organelle
GO:0090160	Golgi to lysosome transport
GO:1902513	regulation of organelle transport along microtubule

Cellular Component

GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005768	endosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005773	vacuole
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0031410	cytoplasmic vesicle
GO:0031982	vesicle
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0043025	neuronal cell body
GO:0044194	cytolytic granule
GO:0061474	phagolysosome membrane
GO:0070062	extracellular vesicular exosome
GO:0097208	alveolar lamellar body

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000185896

View Gene Order

ENSBTAG00000010242

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04142

Lysosome pathway

mmu04145

Phagosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04142

Lysosome pathway

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

P11438

TrEMBL

Q3TA96 Q9DC13

UniProt Splice Variant

Entrez Gene

16783

UniGene

Mm.16716 Mm.475822

RefSeq

NM_010684

OMIM

CCDS

CCDS22106

HPRD

IMGT

MGI ID

MGI:96745

MGI Symbol

Lamp1

EMBL

AK004637 AK159096 AK172007 BC049097 CH466566 J03881 M25244 M32015

GenPept

AAA39411 AAA39428 AAA39869 AAH49097 BAB23428 BAE34812 BAE42773 EDL22121 EDL22123

RNA Seq Atlas

16783