Version 5.4
Mus musculus Gene: Rpl7
Summary
InnateDB Gene IDBG-135044.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rpl7
Gene Name ribosomal protein L7
Synonyms Rpl7a; Surf-3
Species Mus musculus
Ensembl Gene ENSMUSG00000043716
Encoded Proteins
IDBP-135046
ribosomal protein L7
IDBP-538609
ribosomal protein L7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147604:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:16101295-16104662
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000058437 ENSMUSP00000071616
ENSMUST00000140597
ENSMUST00000141217
ENSMUST00000151017
ENSMUST00000149566 ENSMUSP00000118695
ENSMUST00000125005
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 113 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000147604
View Gene Order
ENSBTAG00000020139
Not yet available
Pathways
NETPATH
REACTOME
REACT_253640
Peptide chain elongation pathway
REACT_254308
Translation pathway
REACT_231519
Eukaryotic Translation Termination pathway
REACT_198522
Nonsense-Mediated Decay (NMD) pathway
REACT_247926
Metabolism of proteins pathway
REACT_198528
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_198524
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_229570
Cap-dependent Translation Initiation pathway
REACT_262064
Eukaryotic Translation Initiation pathway
REACT_196445
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_232254
Eukaryotic Translation Elongation pathway
REACT_249044
Formation of a pool of free 40S subunits pathway
REACT_233572
Gene Expression pathway
REACT_259469
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_262078
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
KEGG
mmu03010
Ribosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_24
TSLP pathway
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_75768
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1986
Eukaryotic Translation Termination pathway
REACT_1404
Peptide chain elongation pathway
REACT_1477
Eukaryotic Translation Elongation pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_9491
Viral mRNA Translation pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_6167
Influenza Infection pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_6145
Influenza Life Cycle pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_221721
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_246268
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_202833
Peptide chain elongation pathway
REACT_225310
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_226022
Gene Expression pathway
REACT_218564
Eukaryotic Translation Initiation pathway
REACT_225918
Cap-dependent Translation Initiation pathway
REACT_222208
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_216229
Formation of a pool of free 40S subunits pathway
REACT_209048
Translation pathway
REACT_202903
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_213782
Metabolism of proteins pathway
REACT_222777
Nonsense-Mediated Decay (NMD) pathway
REACT_201931
Eukaryotic Translation Termination pathway
REACT_225811
Eukaryotic Translation Elongation pathway
KEGG
hsa03010
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt P14148
TrEMBL Q5M9N8
UniProt Splice Variant
Entrez Gene 19989
UniGene Mm.379004 Mm.399888 Mm.431604
RefSeq NM_011291
OMIM
CCDS CCDS14829
HPRD
IMGT
MGI ID MGI:98073
MGI Symbol Rpl7
EMBL AK050656 AK088291 AK146219 AK168137 BC025909 BC051261 BC086786 BC096452 M29015 M29016 M85235 X57960 X57961
GenPept AAA40064 AAA40069 AAA40070 AAH25909 AAH51261 AAH86786 AAH96452 BAC34366 BAC40262 BAE26987 BAE40105 CAA41028 CAA41029
RNA Seq Atlas 19989

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca