Mus musculus Gene: Tfdp1
Summary
InnateDB Gene IDBG-135121.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tfdp1
Gene Name transcription factor Dp 1
Synonyms Dp1; Drtf1
Species Mus musculus
Ensembl Gene ENSMUSG00000038482
Encoded Proteins
transcription factor Dp 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198176:
This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:13339674-13377702
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000170909 ENSMUSP00000127952
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0008544 epidermis development
GO:0043276 anoikis
GO:0045893 positive regulation of transcription, DNA-templated
GO:2000278 regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Cell Cycle, Mitotic pathway
G1 Phase pathway
Disease pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
Loss of Function of SMAD4 in Cancer pathway
G0 and Early G1 pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Cell Cycle pathway
Cyclin D associated events in G1 pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
Gene Expression pathway
G1/S-Specific Transcription pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
E2F mediated regulation of DNA replication pathway
Generic Transcription Pathway pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
KEGG
TGF-beta signaling pathway pathway
Cell cycle pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TGF_beta_Receptor pathway
REACTOME
G0 and Early G1 pathway
G1/S-Specific Transcription pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
E2F mediated regulation of DNA replication pathway
Cyclin D associated events in G1 pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
Pre-NOTCH Transcription and Translation pathway
Activation of NOXA and translocation to mitochondria pathway
Activation of PUMA and translocation to mitochondria pathway
Generic Transcription Pathway pathway
G1 Phase pathway
Cellular responses to stress pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Oncogene Induced Senescence pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Pre-NOTCH Expression and Processing pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Mitotic G1-G1/S phases pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
G1/S Transition pathway
Apoptosis pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Cell Cycle pathway
Activation of BH3-only proteins pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
Cellular Senescence pathway
Signaling by NOTCH pathway
TGFBR1 KD Mutants in Cancer pathway
Cell Cycle, Mitotic pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Intrinsic Pathway for Apoptosis pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Oxidative Stress Induced Senescence pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
G0 and Early G1 pathway
Generic Transcription Pathway pathway
Mitotic G1-G1/S phases pathway
Loss of Function of TGFBR1 in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Cyclin D associated events in G1 pathway
G1/S Transition pathway
G1 Phase pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Gene Expression pathway
Cell Cycle, Mitotic pathway
E2F mediated regulation of DNA replication pathway
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
Cell Cycle pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Signal Transduction pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
G1/S-Specific Transcription pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Disease pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
KEGG
TGF-beta signaling pathway pathway
Cell cycle pathway
INOH
PID NCI
Regulation of retinoblastoma protein
Direct p53 effectors
E2F transcription factor network
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt Q08639
TrEMBL Q3V3X3 Q9CYZ7
UniProt Splice Variant
Entrez Gene 21781
UniGene
RefSeq NM_001291765 NM_001291766 NM_001291768 NM_009361 XM_006508750 XM_006508751 XM_006508752 XM_006508753 XM_006508758
OMIM
CCDS CCDS22110
HPRD
IMGT
MGI ID MGI:101934
MGI Symbol Tfdp1
EMBL AK013180 AK030820 AK154037 BC132567 BC132569 BC145344 CH466566 X72310
GenPept AAI32568 AAI32570 AAI45345 BAB28695 BAE20457 BAE32330 CAA51056 EDL22141
RNA Seq Atlas 21781