Mus musculus Gene: Brd8
Summary
InnateDB Gene IDBG-135252.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Brd8
Gene Name bromodomain containing 8
Synonyms 2610007E11Rik; 4432404P07Rik; SMAP;
Species Mus musculus
Ensembl Gene ENSMUSG00000003778
Encoded Proteins
bromodomain containing 8
bromodomain containing 8
bromodomain containing 8
bromodomain containing 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112983:
The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:34598615-34624601
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000003876 ENSMUSP00000003876
ENSMUST00000097626 ENSMUSP00000095229
ENSMUST00000115766 ENSMUSP00000111432
ENSMUST00000115765 ENSMUSP00000111431
ENSMUST00000152612
ENSMUST00000153569
ENSMUST00000145431
ENSMUST00000127159
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0040008 regulation of growth
GO:0043967 histone H4 acetylation
GO:0043968 histone H2A acetylation
Cellular Component
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0035267 NuA4 histone acetyltransferase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Chromatin organization pathway
HATs acetylate histones pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
HATs acetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D3YZC8
UniProt Splice Variant
Entrez Gene 78656
UniGene Mm.408164 Mm.413466 Mm.449199 Mm.45602
RefSeq XM_006526354 XM_006526359 XM_006526360 XM_006526361 NM_030147 NM_001289607 NM_001289606 XM_006526356 XM_006526357
OMIM
CCDS CCDS50248 CCDS70880 CCDS70879
HPRD
IMGT
MGI ID MGI:1925906
MGI Symbol Brd8
EMBL AC074335
GenPept
RNA Seq Atlas 78656