Version 5.4
Homo sapiens Gene: IL5RA
Summary
InnateDB Gene IDBG-13590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL5RA
Gene Name interleukin 5 receptor, alpha
Synonyms CD125; CDw125; HSIL5R3; IL5R
Species Homo sapiens
Ensembl Gene ENSG00000091181
Encoded Proteins
IDBP-13592
interleukin 5 receptor, alpha
IDBP-13598
interleukin 5 receptor, alpha
IDBP-13600
interleukin 5 receptor, alpha
IDBP-360715
interleukin 5 receptor, alpha
IDBP-360717
interleukin 5 receptor, alpha
IDBP-360722
interleukin 5 receptor, alpha
IDBP-360725
interleukin 5 receptor, alpha
IDBP-360727
interleukin 5 receptor, alpha
IDBP-360728
interleukin 5 receptor, alpha
IDBP-360730
interleukin 5 receptor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:3066326-3126613
Strand Reverse strand
Band p26.2
Transcripts
ENST00000256452 ENSP00000256452
ENST00000383846 ENSP00000373358
ENST00000311981 ENSP00000309196
ENST00000446632 ENSP00000412209
ENST00000418488 ENSP00000388858
ENST00000438560 ENSP00000390753
ENST00000430514 ENSP00000400400
ENST00000456302 ENSP00000392059
ENST00000445701 ENSP00000398117
ENST00000427088 ENSP00000391274
ENST00000466722
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0004914 interleukin-5 receptor activity
GO:0005515 protein binding
Biological Process
GO:0002437 inflammatory response to antigenic stimulus
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0019221 cytokine-mediated signaling pathway
GO:0032674 regulation of interleukin-5 production
GO:0038043 interleukin-5-mediated signaling pathway
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005364
View Gene Order
ENSBTAG00000000273
Not yet available
Pathways
NETPATH
NetPath_17
IL5 pathway
REACTOME
REACT_23891
Interleukin receptor SHC signaling pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_6900
Immune System pathway
REACT_22232
Signaling by Interleukins pathway
REACT_604
Hemostasis pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
IL-5 signaling pathway
PID NCI
il5_pathway
IL5-mediated signaling events
Cross-References
SwissProt Q01344
TrEMBL C9J3K8 C9J6C4
UniProt Splice Variant
Entrez Gene 3568
UniGene Hs.68876
RefSeq NM_175725 NM_000564 NM_001243099 NM_175724 NM_175726 NM_175727 NM_175728
HUGO HGNC:6017
OMIM 147851
CCDS CCDS2560 CCDS2559 CCDS46739 CCDS58813
HPRD 00998
IMGT
EMBL AB288090 AC022002 AC024060 AK304256 AY642135 M75914 M96651 M96652 X61176 X62156
GenPept AAA36110 AAA59151 AAA59152 AAT45457 BAG49562 BAG65122 CAA43483 CAA44081
RNA Seq Atlas 3568

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca