InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Map4k2

Summary

InnateDB Gene

IDBG-135906.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map4k2

Gene Name

mitogen-activated protein kinase kinase kinase kinase 2

Synonyms

AI385662; BL44; GCK; Rab8ip

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024948

Encoded Proteins

IDBP-135908

mitogen-activated protein kinase kinase kinase kinase 2

IDBP-535737

mitogen-activated protein kinase kinase kinase kinase 2

IDBP-534058

mitogen-activated protein kinase kinase kinase kinase 2

IDBP-541963

mitogen-activated protein kinase kinase kinase kinase 2

IDBP-533416

mitogen-activated protein kinase kinase kinase kinase 2

IDBP-537665

mitogen-activated protein kinase kinase kinase kinase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168067:
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:6341135-6355615

Strand

Forward strand

Band

Transcripts

ENSMUST00000025897	ENSMUSP00000025897
ENSMUST00000133696
ENSMUST00000152349	ENSMUSP00000115741
ENSMUST00000149624
ENSMUST00000124556	ENSMUSP00000121375
ENSMUST00000148410
ENSMUST00000130382	ENSMUSP00000120123
ENSMUST00000142496	ENSMUSP00000114243
ENSMUST00000124333
ENSMUST00000127809
ENSMUST00000155569
ENSMUST00000123468
ENSMUST00000152259
ENSMUST00000134307
ENSMUST00000152912
ENSMUST00000126841
ENSMUST00000137095
ENSMUST00000154900
ENSMUST00000128170	ENSMUSP00000121856
ENSMUST00000140098
ENSMUST00000155655
ENSMUST00000142862

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008349	MAP kinase kinase kinase kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031435	mitogen-activated protein kinase kinase kinase binding

Biological Process

GO:0000165	MAPK cascade
GO:0000185	activation of MAPKKK activity
GO:0006468	protein phosphorylation
GO:0006903	vesicle targeting
GO:0007257	activation of JUN kinase activity
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response
GO:0046330	positive regulation of JNK cascade