InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ifngr1

Summary

InnateDB Gene

IDBG-135936.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ifngr1

Gene Name

interferon gamma receptor 1

Synonyms

CD119; Ifgr; IFN-gammaR; Ifngr; Nktar

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020009

Encoded Proteins

IDBP-135938

interferon gamma receptor 1

IDBP-628046

interferon gamma receptor 1

IDBP-628047

interferon gamma receptor 1

IDBP-628048

interferon gamma receptor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 27220602

Expression of Cxcl13, Ifngr1, Retnla and Mrc1 distinguishes between large and small resident peritoneal macrophage subsets.

InnateDB Annotation from Orthologs

Summary

PMID 16785527

[Homo sapiens] IFNGR1, along with IFNGR2, are the receptor subunits for IFN-gamma that upon ligand binding, translocate to the nucleus together with STAT1-alpha, and associate with IFN-gamma-activated sequence (GAS) elements at the promoter sites of IFN-gamma-activated genes.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000027697:
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:19591949-19610229

Strand

Forward strand

Band

Transcripts

ENSMUST00000020188	ENSMUSP00000020188
ENSMUST00000110989
ENSMUST00000164591	ENSMUSP00000129309
ENSMUST00000171772	ENSMUSP00000127219
ENSMUST00000172253	ENSMUSP00000127484
ENSMUST00000168074

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019955	cytokine binding

Biological Process

GO:0045087

innate immune response (InnateDB)

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0031982	vesicle