Mus musculus Gene: Klhl13
Summary
InnateDB Gene IDBG-136215.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Klhl13
Gene Name kelch-like 13 (Drosophila)
Synonyms 1200009K10Rik; AI451128; Bklhd2; D130072F20Rik; mKIAA1309
Species Mus musculus
Ensembl Gene ENSMUSG00000036782
Encoded Proteins
kelch-like 13 (Drosophila)
kelch-like 13 (Drosophila)
kelch-like 13 (Drosophila)
kelch-like 13 (Drosophila)
kelch-like 13 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000003096:
This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:23219271-23365082
Strand Reverse strand
Band A2
Transcripts
ENSMUST00000035973 ENSMUSP00000041190
ENSMUST00000115319 ENSMUSP00000110974
ENSMUST00000115317 ENSMUSP00000110972
ENSMUST00000115316 ENSMUSP00000110971
ENSMUST00000115313 ENSMUSP00000110968
ENSMUST00000144360
ENSMUST00000153345
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0000910 cytokinesis
GO:0007067 mitotic nuclear division
GO:0016567 protein ubiquitination
Cellular Component
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Class I MHC mediated antigen processing & presentation pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
KEGG
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Aurora B signaling
Cross-References
SwissProt Q80TF4
TrEMBL Q9CSA7
UniProt Splice Variant
Entrez Gene 67455
UniGene
RefSeq XM_006527695 NM_001290476 NM_026167 XM_006527696
OMIM
CCDS CCDS40891 CCDS72348
HPRD
IMGT
MGI ID MGI:1914705
MGI Symbol Klhl13
EMBL AK004677 AK013399 AK122491 AL773552
GenPept BAB23465 BAB28832 BAC65773 CAM13384 CAM13385 CAM13386 CAM13387
RNA Seq Atlas 67455