Version 5.4
Mus musculus Gene: Bag1
Summary
InnateDB Gene IDBG-136600.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bag1
Gene Name BCL2-associated athanogene 1
Synonyms BAG-1; Rap46
Species Mus musculus
Ensembl Gene ENSMUSG00000028416
Encoded Proteins
IDBP-136602
BCL2-associated athanogene 1
IDBP-265268
BCL2-associated athanogene 1
IDBP-789967
BCL2-associated athanogene 1
IDBP-789968
BCL2-associated athanogene 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to Bcl2 protein and is referred to as Bcl2-associated athanogene. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:40936398-40948294
Strand Reverse strand
Band A5
Transcripts
ENSMUST00000030125 ENSMUSP00000030125
ENSMUST00000108089 ENSMUSP00000103724
ENSMUST00000191273 ENSMUSP00000139864
ENSMUST00000189377 ENSMUSP00000140923
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051087 chaperone binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0006915 apoptotic process
GO:0030182 neuron differentiation
GO:0043066 negative regulation of apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070585 protein localization to mitochondrion
GO:2000672 negative regulation of motor neuron apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000107262
View Gene Order
ENSBTAG00000017845
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
ap1_pathway
AP-1 transcription factor network
Cross-References
SwissProt Q60739
TrEMBL
UniProt Splice Variant
Entrez Gene 12017
UniGene Mm.688
RefSeq NM_001171739 NM_009736
OMIM
CCDS CCDS51139 CCDS38713
HPRD
IMGT
MGI ID MGI:108047
MGI Symbol Bag1
EMBL AF022223 AK009149 AL837521 BC003722 BC069918 BC093509 CH466538
GenPept AAC34259 AAH03722 AAH69918 AAH93509 BAB26106 CAM19843 EDL05422
RNA Seq Atlas 12017

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca