Homo sapiens Gene: ABCA7
Summary
InnateDB Gene IDBG-13665.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCA7
Gene Name ATP-binding cassette, sub-family A (ABC1), member 7
Synonyms ABCA-SSN; ABCX;
Species Homo sapiens
Ensembl Gene ENSG00000064687
Encoded Proteins
ATP-binding cassette, sub-family A (ABC1), member 7
ATP-binding cassette, sub-family A (ABC1), member 7
ATP-binding cassette, sub-family A (ABC1), member 7
ATP-binding cassette, sub-family A (ABC1), member 7
ATP-binding cassette, sub-family A (ABC1), member 7
ATP-binding cassette, sub-family A (ABC1), member 7
ATP-binding cassette, sub-family A (ABC1), member 7
ATP-binding cassette, sub-family A (ABC1), member 7
ATP-binding cassette, sub-family A (ABC1), member 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:1040101-1065572
Strand Forward strand
Band p13.3
Transcripts
ENST00000263094 ENSP00000263094
ENST00000433129 ENSP00000414062
ENST00000435683 ENSP00000465322
ENST00000530703
ENST00000524850 ENSP00000431473
ENST00000526885
ENST00000525238
ENST00000531467 ENSP00000433545
ENST00000527496
ENST00000533574
ENST00000530092 ENSP00000437311
ENST00000525073 ENSP00000432031
ENST00000529442 ENSP00000480811
ENST00000532194
ENST00000525939
ENST00000531478
ENST00000524383
ENST00000611490 ENSP00000478857
ENST00000612569 ENSP00000482948
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005524 ATP binding
GO:0005548 phospholipid transporter activity
GO:0016887 ATPase activity
GO:0034188 apolipoprotein A-I receptor activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006909 phagocytosis
GO:0007613 memory
GO:0010875 positive regulation of cholesterol efflux
GO:0017121 phospholipid scrambling
GO:0018149 peptide cross-linking
GO:0032780 negative regulation of ATPase activity
GO:0032781 positive regulation of ATPase activity
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034380 high-density lipoprotein particle assembly
GO:0034504 protein localization to nucleus
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
GO:0050766 positive regulation of phagocytosis
GO:0055085 transmembrane transport
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:1900223 positive regulation of beta-amyloid clearance
GO:1901076 positive regulation of engulfment of apoptotic cell
GO:1902430 negative regulation of beta-amyloid formation
GO:1902995 positive regulation of phospholipid efflux
Cellular Component
GO:0000139 Golgi membrane
GO:0001891 phagocytic cup
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0032587 ruffle membrane
GO:0043190 ATP-binding cassette (ABC) transporter complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
ABCA transporters in lipid homeostasis pathway
ABC-family proteins mediated transport pathway
KEGG
ABC transporters pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL B3KUJ3
UniProt Splice Variant
Entrez Gene 10347
UniGene Hs.134514
RefSeq NM_019112 XM_006722617 XM_006722618
HUGO HGNC:37
OMIM 605414
CCDS CCDS12055
HPRD 09255
IMGT
EMBL AK097344
GenPept BAG53455
RNA Seq Atlas 10347