InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vcl

Summary

InnateDB Gene

IDBG-136687.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vcl

Gene Name

vinculin

Synonyms

9430097D22; AA571387; AI462105; AW545629

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021823

Encoded Proteins

IDBP-136691

vinculin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000035403:
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:20929433-21033673

Strand

Forward strand

Band

Transcripts

ENSMUST00000022369

ENSMUSP00000022369

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 141 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	141 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002162	dystroglycan binding
GO:0003779	actin binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0045294	alpha-catenin binding

Biological Process

GO:0002009	morphogenesis of an epithelium
GO:0007155	cell adhesion
GO:0030032	lamellipodium assembly
GO:0030334	regulation of cell migration
GO:0034333	adherens junction assembly
GO:0034394	protein localization to cell surface
GO:0043297	apical junction assembly
GO:0090136	epithelial cell-cell adhesion

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005916	fascia adherens
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0043034	costamere
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome