Version 5.4
Mus musculus Gene: Yars2
Summary
InnateDB Gene IDBG-136778.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Yars2
Gene Name tyrosyl-tRNA synthetase 2 (mitochondrial)
Synonyms 2210023C10Rik; tyrRS
Species Mus musculus
Ensembl Gene ENSMUSG00000022792
Encoded Proteins
IDBP-136780
tyrosyl-tRNA synthetase 2 (mitochondrial)
IDBP-542663
tyrosyl-tRNA synthetase 2 (mitochondrial)
IDBP-535681
tyrosyl-tRNA synthetase 2 (mitochondrial)
IDBP-540251
tyrosyl-tRNA synthetase 2 (mitochondrial)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139131:
This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:16302965-16309640
Strand Forward strand
Band A2
Transcripts
ENSMUST00000059955 ENSMUSP00000055277
ENSMUST00000159962 ENSMUSP00000125252
ENSMUST00000161191
ENSMUST00000159683 ENSMUSP00000124606
ENSMUST00000159583
ENSMUST00000162734 ENSMUSP00000125496
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
GO:0072545 tyrosine binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000139131
View Gene Order
ENSBTAG00000011399
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00970
Aminoacyl-tRNA biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15302
Mitochondrial tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00970
Aminoacyl-tRNA biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.37486
RefSeq NM_198246
OMIM
CCDS CCDS27983
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca