Version 5.4
Homo sapiens Gene: GSTZ1
Summary
InnateDB Gene IDBG-13687.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSTZ1
Gene Name glutathione S-transferase zeta 1
Synonyms GSTZ1-1; MAAI; MAI
Species Homo sapiens
Ensembl Gene ENSG00000100577
Encoded Proteins
IDBP-13689
glutathione transferase zeta 1
IDBP-13691
glutathione transferase zeta 1
IDBP-13693
glutathione transferase zeta 1
IDBP-243023
glutathione transferase zeta 1
IDBP-594374
glutathione transferase zeta 1
IDBP-592893
glutathione transferase zeta 1
IDBP-584648
glutathione transferase zeta 1
IDBP-585077
glutathione transferase zeta 1
IDBP-592189
glutathione transferase zeta 1
IDBP-596408
glutathione transferase zeta 1
IDBP-595439
glutathione transferase zeta 1
IDBP-583322
glutathione transferase zeta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:77320884-77331597
Strand Forward strand
Band q24.3
Transcripts
ENST00000216465 ENSP00000216465
ENST00000349555 ENSP00000314404
ENST00000361389 ENSP00000354959
ENST00000393734 ENSP00000377335
ENST00000553838
ENST00000554279 ENSP00000452498
ENST00000557639 ENSP00000451927
ENST00000553770
ENST00000553431
ENST00000556627 ENSP00000450487
ENST00000557053 ENSP00000451150
ENST00000553268
ENST00000554846 ENSP00000452531
ENST00000556914
ENST00000555093
ENST00000553586 ENSP00000451976
ENST00000555583 ENSP00000452346
ENST00000554381 ENSP00000451850
ENST00000555208
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0005515 protein binding
GO:0016034 maleylacetoacetate isomerase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006559 L-phenylalanine catabolic process
GO:0006572 tyrosine catabolic process
GO:0006749 glutathione metabolic process
GO:0006805 xenobiotic metabolic process
GO:0009072 aromatic amino acid family metabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021033
View Gene Order
ENSBTAG00000002706
Not yet available
Pathways
NETPATH
REACTOME
REACT_1786
Phenylalanine and tyrosine catabolism pathway
REACT_6926
Glutathione conjugation pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00350
Tyrosine metabolism pathway
INOH
INOH website
Tyrosine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL G3V267
UniProt Splice Variant
Entrez Gene 2954
UniGene Hs.655292
RefSeq NM_001513 NM_145870 NM_145871
HUGO HGNC:4643
OMIM 603758
CCDS CCDS9858 CCDS9859 CCDS9860
HPRD 04785
IMGT
EMBL AC007954
GenPept
RNA Seq Atlas 2954

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca