Homo sapiens Gene: GSTZ1
Summary
InnateDB Gene IDBG-13687.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSTZ1
Gene Name glutathione S-transferase zeta 1
Synonyms GSTZ1-1; MAAI; MAI;
Species Homo sapiens
Ensembl Gene ENSG00000100577
Encoded Proteins
glutathione transferase zeta 1
glutathione transferase zeta 1
glutathione transferase zeta 1
glutathione transferase zeta 1
glutathione transferase zeta 1
glutathione transferase zeta 1
glutathione transferase zeta 1
glutathione transferase zeta 1
glutathione transferase zeta 1
glutathione transferase zeta 1
glutathione transferase zeta 1
glutathione transferase zeta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:77320884-77331597
Strand Forward strand
Band q24.3
Transcripts
ENST00000216465 ENSP00000216465
ENST00000349555 ENSP00000314404
ENST00000361389 ENSP00000354959
ENST00000393734 ENSP00000377335
ENST00000553838
ENST00000554279 ENSP00000452498
ENST00000557639 ENSP00000451927
ENST00000553770
ENST00000553431
ENST00000556627 ENSP00000450487
ENST00000557053 ENSP00000451150
ENST00000553268
ENST00000554846 ENSP00000452531
ENST00000556914
ENST00000555093
ENST00000553586 ENSP00000451976
ENST00000555583 ENSP00000452346
ENST00000554381 ENSP00000451850
ENST00000555208
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0005515 protein binding
GO:0016034 maleylacetoacetate isomerase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006559 L-phenylalanine catabolic process
GO:0006572 tyrosine catabolic process
GO:0006749 glutathione metabolic process
GO:0006805 xenobiotic metabolic process
GO:0009072 aromatic amino acid family metabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Glutathione conjugation pathway
Phenylalanine and tyrosine catabolism pathway
Metabolism of amino acids and derivatives pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Tyrosine metabolism pathway
INOH
Tyrosine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655292
RefSeq NM_001513 NM_145870 NM_145871
HUGO
OMIM
CCDS CCDS9858 CCDS9859 CCDS9860
HPRD 04785
IMGT
EMBL
GenPept
RNA Seq Atlas